Antimicrobial Drugs
The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called
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- The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called (MBPL3822 Chemotherapy CAT 1 MCQs)
- The following antimicrobial drugs act on the 50S subunit of the bacterial ribosome:A) Chloramphenicol, Erythromycin (Molecular Biology,Molecular Genetics & Microbial-Biochemistry MCQs)
Study material on Antimicrobial Drugs
Practice questions on Antimicrobial Drugs
The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called
- Concentration-dependent killing
- Sequential blockade
- Clinical synergy
- The post antibiotic effect
- Time-dependent killing
Answer: D. The post-antibiotic effect (PAE) is the continued suppression of bacterial growth after brief exposure to an antimicrobial agent, even after drug concentrations have fallen below the MIC. This is particularly notable with aminoglycosides and fluoroquinolones. ---
Which type of antimicrobial drug combination is most likely to exhibit antagonism?
- Bacteriostatic + Bacteriostatic for a highly resistant organism
- Bactericidal + Bactericidal for a marginally sensitive organism
- Antagonism
- Bactericidal + Bacteriostatic for a highly sensitive organism
- Primarily an incidental laboratory finding
Answer: C. Antagonism is most likely when combining bactericidal and bacteriostatic agents, especially for marginally sensitive organisms. Bactericidal drugs (like β-lactams) work best on actively dividing bacteria, but bacteriostatic drugs stop bacterial growth/division. This can reduce the effectiveness of the bactericidal agent. ---
The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called the post-antibiotic effect (PAE). This is particularly relevant for aminoglycosides.
- A) Post-antibiotic effect
- B) Minimum inhibitory concentration
- C) Minimum bactericidal concentration
- D) Sub-inhibitory effect
Answer: A. The post-antibiotic effect (PAE) is the period during which bacterial growth is suppressed after the concentration of an antimicrobial drug has fallen below the minimum inhibitory concentration (MIC). Aminoglycosides, in particular, exhibit a significant PAE.
The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called:
- Bactericidal effect
- Bacteriostatic effect
- Post-antibiotic effect
- Minimum inhibitory concentration (MIC)
Answer: C. The post-antibiotic effect (PAE) is the persistent suppression of bacterial growth after exposure to an antibiotic has ceased. This is a key pharmacodynamic property.
The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs, even after drug concentrations have fallen below the minimum inhibitory concentration (MIC), is called:
- Bacteriostatic effect
- Minimum bactericidal concentration (MBC)
- Post-antibiotic effect (PAE)
- Antibiotic resistance
Answer: C. The post-antibiotic effect (PAE) describes the continued suppression of bacterial growth after antibiotic levels have dropped below the MIC. It's an important pharmacokinetic/pharmacodynamic parameter for antibiotic dosing.