Helicobacter Pylori
Upper GI endoscopy is performed and gastric biopsies are taken that on microscopic examination reveal acute and chronic mucosal inflammation along with the presence of Helicobacter pylori organisms.
Helicobacter pylori:
- B. Adheres to the gastric mucosa in an alkaline layer
- C. Is never seen in healthy people
- D. Can be simply identified in the endoscopy room by its urease activity
- E. Is associated with peptic ulcer relapse
Read this in Internal Medicine (MBIM 4100) main exam, Paper One: 3 July 2019
What our notes say
- Upper GI endoscopy is performed and gastric biopsies are taken that on microscopic examination reveal acute and chronic mucosal inflammation along with the presence of Helicobacter pylori organisms. (Gastrointestinal and liver — Past Paper Questions & Answers)
- Test for Helicobacter pylori and review the use of NSAIDs afterwards. (Surgery Question Bank: 12 Clinical MCQs)
- Causes: *Helicobacter pylori* infection, NSAID use, Zollinger-Ellison syndrome (Pathology Practical Revision Guide)
- Give a brief outline of the virulence factors linked to Helicobacter pylori implicated in the pathogenesis of chronic gastritis (8 marks) (Gi sem2 patho — Past Paper Questions & Answers)
- Chronic *Helicobacter pylori* infection contributes to gastric carcinoma mainly by: (General Pathology MCQs: Cancer, Tumors & Molecular Path Review)
- Helicobacter pylori possesses that helps to neutralize stomach acid (HCl). (Medical Bacteriology And Parasitology End Year 2024/2025)
Study material on Helicobacter Pylori
Practice questions on Helicobacter Pylori
Helicobacter pylori possesses that helps to neutralize stomach acid (HCl).
- Coagulase
- Urease
- Hyaluronidase
- Catalase
- Lipase
Answer: B. H. pylori produces urease, which makes ammonia and neutralises stomach acid. ---
A 60-year-old man has had abdominal pain and early satiety for 8 months. He has a history of Helicobacter pylori gastritis. Endoscopy shows a gastric mucosal mass. Biopsy shows a low-grade B-cell lymphoma composed of small lymphocytes infiltrating the mucosa. Most likely diagnosis?
- Diffuse large B-cell lymphoma
- Mantle cell lymphoma
- Marginal zone lymphoma (MALT lymphoma)
- Burkitt lymphoma
Answer: C. H. pylori gastritis + low-grade B-cell mucosal lymphoma = gastric MALT lymphoma (marginal zone lymphoma). H. pylori antigen chronically stimulates mucosal B cells leading to clonal proliferation. Early cases may regress with H. pylori eradication. ---
Chronic Helicobacter pylori infection contributes to gastric carcinoma mainly by:
- Decreasing gastric acidity
- Inducing chronic inflammation and reactive oxygen species production
- Inhibiting epithelial proliferation
- Increasing DNA repair enzyme activity
- Direct viral transformation
Answer: B. Chronic H. pylori infection
Helicobacter pylori possesses that helps to neutralize stomach acid (HCl). ---
- Coagulase
- Urease
- Hyaluronidase
- Catalase
- Lipase
Answer: A.
Chronic *Helicobacter pylori* infection contributes to gastric carcinoma mainly by ---
- Decreasing gastric acidity
- Inducing chronic inflammation and reactive oxygen species production
- Inhibiting epithelial proliferation
- Increasing DNA repair enzyme activity
- Direct viral transformation
Answer: B.