Human Papillomavirus
Also written as HPV.
Risk factors/aetiology: persistent infection with high-risk Human Papillomavirus (HPV) — chiefly types 16 and 18 — is the central causal factor.
Human Papillomavirus (HPV)
- Genome: dsDNA, non-enveloped
- Oncogenic types: HPV 16 and HPV 18 — cause 70% of cervical cancers
- Low-risk types: HPV 6 and 11 — cause genital warts (condylomata acuminata)
- Mechanism of oncogenesis:
- HPV infects basal epithelial cells of cervical transformation zone
Read this in EXAM: Hepatitis Viruses, Oncogenic Viruses, Paramyxoviruses & Arboviruses
What our notes say
- Risk factors/aetiology: persistent infection with high-risk Human Papillomavirus (HPV) — chiefly types 16 and 18 — is the central causal factor. (General & Systemic Pathology SAQ Paper II — 15 July 2025 (MBPA 3500, MKU Year 3,)
- Human Papillomavirus (HPV) and Parvovirus B19 are both non-enveloped DNA viruses that cause important clinical diseases. (EXAM: Bacteriophages, Laboratory Diagnosis, HPV & Parvovirus B19)
- Etiology: Human Papillomavirus (HPV) infection is the primary etiologic agent, particularly high-risk types 16 and 18. (General Pathology Q&A)
- Rotavirus, pentavalent and pneumococcal vaccines start at 6 weeks, measles-containing vaccines from 9 months, and human papillomavirus vaccine in adolescence. (Paediatrics Question Bank: 12 Clinical MCQs)
- A 35-year-old has a normal Pap smear and a positive high-risk human papillomavirus test. (Obstetrics and Gynaecology Question Bank: 12 Clinical MCQs)
- Persistent infection of cervical basal cells at the squamocolumnar junction by high-risk Human Papillomavirus (HPV) types (e.g., HPV 16, 18). (Female rep y3 — Past Paper Questions & Answers)
Study material on Human Papillomavirus
- EXAM: Bacteriophages, Laboratory Diagnosis, HPV & Parvovirus B19
- Female Reproductive Pathology: HPV, Cancer, PCOS & Pregnancy
- Female system
- Female rep y3
- EXAM: Hepatitis Viruses, Oncogenic Viruses, Paramyxoviruses & Arboviruses
- General Pathology Q&A
- Skin & Breast Pathology MCQs: Dermatological Lesions & Diseases
- Obstetrics and Gynaecology Question Bank: 12 Clinical MCQs
- Medical Virology: Hepatitis, Viral Carcinogenesis & Oncogenic Viruses
- Pathology of Acute Skin Inflammation: Urticaria & Eczema
- Respiratory System Pathology 1A — Practice Questions