Jakob Disease
Also written as CJD.
Creutzfeldt-Jakob Disease (CJD) — sporadic, familial or acquired
What our notes say
- Creutzfeldt-Jakob Disease (CJD) — sporadic, familial or acquired (Medical Microbiology III Exam: Viruses, Fungi & Diagnosis)
- Creutzfeldt-Jakob Disease (CJD) — most common; sporadic, familial, or iatrogenic; rapidly progressive dementia, myoclonus, ataxia (Medical Mycology Q&A Section B)
- Cause: Creutzfeldt-Jakob disease, Kuru, Scrapie, Mad Cow disease (Medical Virology Exam Notes: Pathogenesis, HSV, CMV, Hepatitis, Flu)
- Creutzfeldt-Jakob disease (CJD) — sporadic, familial, iatrogenic, and variant (vCJD from BSE-infected beef) (MKU Medical Virology Exam Guide: HIV, CMV, Vaccines & More)
- Human prion diseases:Creutzfeldt-Jakob disease (CJD) – the most common prion disease, often sporadic. (Principles of Medical Microbiology and Parasitology LAQs & SAQs)
Practice questions on Jakob Disease
Creutzfeldt-Jakob disease (CJD), Kuru, scrapie, and Mad Cow disease are caused by
- Viroids
- Retroviruses
- DNA viruses
- Prions
- RNA viruses
Answer: D. Prions are misfolded proteins (PrP^Sc) that cause fatal neurodegenerative spongiform encephalopathies. They contain no nucleic acid — making them unique among all known infectious agents. They are extraordinarily resistant to heat, radiation, and standard disinfection. CJD, Kuru, scrapie (sheep), and variant CJD (Mad Cow) are all prion diseases. ---