A structured postgraduate systemic pathology essay and short-note question archive for advanced revision, transcribed from original examination scans. K...
Systemic Pathology Essay Bank Archive context: These are postgraduate M.D. Pathology examination questions collected from original scanned papers. They are provided as an advanced revision bank, not as model answers or as an official current MBChB paper. Terminology has been lightly standardized while preserving the questions. How to use this archive Practise a timed outline before writing a full essay. Structure disease essays under definition, classification, aetiology, pathogenesis, morphology, clinical features, complications and investigations where applicable. Confirm current classifications in your prescribed pathology text and current WHO guidance. April 2001 Examination Essay questions 1. Discuss recent concepts, classification and pathology of non-Hodgkin lymphoma. (25 marks) 2. Discuss the pathology of ulcerative lesions of the ileum and colon. (25 marks) Brief answers 1. Immunological mechanisms of glomerular injury. 2. Congenital heart diseases. 3. Malignant lesions of the lung. 4. Uses of computers in pathology. 5. Paraneoplastic syndromes. November 2001 Examination Essay questions 1. Discuss the molecular pathology of small round-cell tumours. (25 marks) 2. Classify eccrine sweat-gland tumours and discuss their pathology. (25 marks) Brief answers 1. Metabolic bone disease. 2. Obesity and systemic disorders. 3. Pathology of male infertility. 4. Congenital cystic lesions of the kidney. 5. Ependymoma. March 2002 Examination Essay questions 1. Discuss current concepts in rheumatic heart disease. 2. Discuss the pathology of prion disease. Brief answers 1. Osteogenic sarcoma. 2. Mesothelioma. 3. Parathyroid adenoma. 4. Primary sclerosing cholangitis. 5. Clear-cell tumour of the cervix. September 2002 Examination Essay questions 1. Discuss gestational trophoblastic tumours. 2. Discuss the role of electron microscopy in renal disease. Brief answers 1. Prognostic factors in ovarian cancer. 2. Large-cell lymphomas. 3. Merkel-cell carcinoma. 4. Alpha-1 antitrypsin deficiency. 5. Hepatitis C. April 2003 Examination Essay questions 1. Classify central nervous system tumours and discuss the gross and microscopic features of glial neoplasms. 2. Discuss the aetiology, pathology, types and complications of cardiac vegetations. Brief answers 1. Hermansky–Pudlak syndrome. 2. HIV-associated lymphadenopathy. 3. Colonic polyps. 4. Carcinoid tumours. 5. Small round-cell tumours. October 2003 Examination Essay questions 1. Discuss the pathogenesis and molecular biology of colorectal carcinoma, including morphology and prognostic factors. (15 marks) 2. Define and classify glomerulonephritis, and discuss mechanisms of acute glomerulonephritis. (15 marks) Short notes 1. Classification and differentiation of gastrointestinal carcinoid tumours. 2. Pathobiology of Hirschsprung disease. 3. Classification and pathogenesis of Sjögren syndrome. 4. Teratoma. 5. Aetiopathogenesis of cervical carcinoma. 6. Signet-ring cell lymphoma. 7. Hormone-producing ovarian tumours. 8. Uses of in-situ hybridization. 9. Bone-marrow transplantation. 10. Classification of osteosarcoma. April 2004 Examination Essay questions 1. Classify vasculitis and discuss its aetiology and pathogenesis. (15 marks) 2. Discuss the aetiology and pathology of malabsorption syndromes. (15 marks) Short notes 1. Miliary tuberculosis. 2. Paraganglioma. 3. Oesophagitis. 4. Portal hypertension. 5. Focal segmental glomerulosclerosis. 6. Malignant melanoma. 7. Gout. 8. Peripheral nerve-sheath tumours. 9. Phaeochromocytoma. 10. Sex-cord stromal tumours. August 2004 Examination Essay questions 1. Discuss the pathogenesis and pathology of primary cardiomyopathies. 2. Discuss the diagnostic value of liver biopsy. Short notes 1. Fibroepithelial lesions of the breast. 2. Extranodal lymphomas. 3. Ovarian sex-cord stromal tumours. 4. Interstitial pneumonitis. 5. Primitive neuroectodermal tumours. 6. Muscle biopsy. 7. Non-bacterial thrombotic endocarditis. 8. Giant-cell lesions of bone. 9. Immunofluorescence in skin disorders. 10. Mediastinal tumours. February 2005 Examination Essay questions 1. Classify glomerular diseases and discuss the aetiopathogenesis and pathology of nephrotic syndrome. 2. Discuss the aetiopathogenesis, classification and pathology of lung tumours. Short notes 1. Fibrolamellar carcinoma of the liver. 2. Chordoma. 3. Pathology and complications of myocardial infarction. 4. Perivascular epithelioid-cell tumours (PEComas). 5. Tumour-like lesions of bone. 6. Prostatic intraepithelial neoplasia. 7. Premalignant breast lesions. 8. Trophoblastic tumours. 9. Multiple endocrine neoplasia. 10. Types of lesions in pemphigus. March 2006 Examination Essay questions 1. Discuss the aetiopathogenesis and morphology of colorectal carcinoma. 2. Classify primary muscle diseases and discuss the role of muscle biopsy. Short notes 1. Immunofluorescence in acute glomerulonephritis. 2. Non-alcoholic fatty liver disease. 3. Malignant peripheral nerve-sheath tumour. 4. Immunohisto