Haematology End-of-Year 2025 — Past Paper OmpathStudy

Haematology EOY 2025 — Complete Scanned Examination All 17 scanned pages were processed locally. The printed instructions specify 60 MCQs, seven short-answer questions and one long-answer question. Page context is preserved because handwriting, diagrams and some degraded question numbers cannot safely be flattened into a single inferred sequence. Original page images remain attached and authoritative. Source page 1 GL . ———————————— ———— oo ”-—l Mount K PX Universi ount Kenya University A UNIVERSITY EXAMINATION 2024/2025 SCHOOL OF MEDICINE DEPARTMENT OF PATHOLOGY BACHELOR OF MEDICINE AND BACHELOR OF SURGERY YEAR 3 UNIT CODE: MBML 3200 UNIT TITLE: HAEMATOLOGY DATE: 1474 JULY, 2025 2:00PM MAIN EXAM. TIME: 2HRS 30MINS a i EXAMINATION INSTRUCTIONS Make sure you do not have any mobile phone and other unauthorized electronic devices or any bag, books, papers, pencil cases, coats etc. with you at the exam. venue. Place your University identification card on your desk. Listen carefully to instructions. Students are expected to comply with the instructions from the invigilators at all times. Write your registration number on all the answer booklets you use. Keep your eyes on your own paper. Talking is not allowed at any time in the exarn room. You are not allowed to share pens, erasers, calculators or any other materials during the examination. You are not allowed to leave the examination room during the examination. If you have any question or concern, raise your hand and an invigilator will come to you. Attempt all the questions. — — — — 'l EEE Paper One Page 1 Source page 2 QUESTIONS THIS EXAMINATION CONSISTS OF THREE SECTIONS: A, B & C. ATTEMPT ALL QUESTIONS SECTION A CONSISTS OF 60 MULTIPLE CHOICE QUESTIONS. SELECT THE SINGLE BEST ANSWER FOR EACH QUESTION. ONE MARK WILL BE AWARDED FOR EACH CORRECT RESPONSE. NO MARKS WILL BE DEDUCTED FOR A WRONG ANSWER. SECTION B CONSISTS OF 7 SHORT ANSWER QUESTIONS. EACH QUESTION IS ASSIGNED 35 MARKS. SECTION C CONSISTS OF ONE LONG ANSWER QUESTION CARRYING 20 MARKS, AN ANSWER BOOKLET IS PROVIDED. LEGIBLY WRITE YOUR CHOICE. THE QUESTION PAPER MUST BE HANDED BACK INTACT AT THE END OF THE EXAMINATION. SECTION A: MULTIPLE CHOICE QUESTIONS (MCQs): 60 MARKS 1. A 28-year-old woman presents with fatigue and pallor. Complete blood count show allow haemoglobin level and Peripheral blood film shows microcytic hypochromic red blood cells. What is the most likely diagnosis? " a) Vitamin B12 deficiency b) Iron deficiency anaemia c) Aplastic anaemia d) Haemolytic anaemia e) Sickle cell anaemia 2. The primary site of haematopoiesis in adults is: a) Liver . b) Spleen c) Bone marrow d) Lymph nodes e) Thymus PaperOne ~~~SCSC:CS<CStS Source page 3 a 3. Which blood cell type Is primarlly responsible for defence against parasitic infections? a) Neutrophils b) Basophils c) Eosinophils d) Monocytes e) Lymphocytes 4. Which clotting factor is deficient in Haemophilia A? a) Factor V b) Factor VII c) Factor VIII d) Factor IX e) Factor X 5. A patient presents with recurrent infections, petechiae, and anaemia. A bone marrow biopsy shows reduced cellularity. What is the most likely diagnosis? a) Iron deficiency anaemia b) Sickle cell disease c) Polycythaemia vera d) Aplastic anaemia e) Thalassaemia 6. Haemopoiesis is the process of: a) Blood clot formation b) White blood cell destruction c) Blood cell production d) Plasma protein synthesis e) Iron transport 7. A 62-year-old man presents with fatigue, fever and bruising. His full blood count shows WCC 40 x 10°/L with 25 % circulating blasts, Hb 90 g/L and platelets 50 x 10°/L. Which investigation is required to definitively diagnose acute myeloid leukaemia? a) Bone marrow aspirate and trephine biopsy b) Peripheral blood smear c) Flow cytometry of peripheral blood a EEE——————— Source page 4 $$ A d) Computed tomography scan x, e) Serum lactate dehydrogenase 8. Which cytochemical stain is most useful to confirm lymphoblasts in suspected ALL? a) Myeloperoxidase (MPO) b) Terminal deoxynucleotidyl transferase (TdT) c) Sudan Black B d) Tartrate-resistant acid phosphatase (TRAP) e) Periodic acid-Schiff (PAS) 9. A patient receiving chemotherapy shows a drop in neutrophil count. This condition is termed: a) Anaemia b) Leukocytosis c) Neutropenia d) Thrombocytopenia e) Erythrocytosis 10. Which chromosomal translocation is pathognumeric of chronic myeloid leukaemia? a) t (8;21) b) t (15;17) c) t (9;22) (q34; qil1) d) t (4,11) e) inv (16) 11. Thrombopoietin primarily regulates the production of: a) Red blood cells : b) Plasma cells c) Platelets d) Monocytes e) Eosinophils 12. Which of the following is a stem cell marker used to identify haematopoietic stem cells? a) CD3 b) CD4 CTT EEE Source page 5 c) CD19 d) CD34 e) CD20 13. In a bone marrow biopsy of a patient with aplastic anaemia, you would expect to find: a) Hypercellular marrow with many erythroblasts b) Increased megakaryocytes c) Fatty replacement and hypocellularity d) Increased lymphoid follicles e) Excessive ne