bchem EOY 2015 — Past Paper Questions & Answers

Biochemistry EOY 2015 — Visual Scan Archive All 11 source pages are included. The scan contains diagrams, handwritten/photographic content or pages with too little reliable machine-readable text for a safe flattened question sequence. Original page images are therefore the authoritative paper; usable OCR labels are preserved below. o UNIVERSITY OF NAIROBL EXAMINATIONS 2014/2015 = ’ FIRST XA} : : BACHELOR OF ee EXAMINATIONS FOR THE DEGREE OF ix er CINE AND BACHELOR OF SURGERY, BACHELOR OF PHARMACY & BACHELOR OF DENTAL SURGERY . HBC 100/UPC 102/VBC100: BIOCHEMISTRY ———————————————————EEEEEEeEeEeEeEes SECTION A: (30 MARKS): Attempt any THREE Questions. y = The inner mitochondrial membrane is impermeable to many moleciles except to those with : specific carriers or permeases. Describe the mechanism through which extra-mitochondrial , NADH is delivered into the mitochondrial matrix for oxidation in the election transport ; chain. BP, ¢ ri Indicate the. name and write a-detailed reaction that is catalysed by each of the foflowing a = enzymes and clearly indicating whether the reaction is reversible or irreversible; @ G3P to DHAP converting enzyme. . (be) OAA and acetylCoA condensing enzyme. - (©) A PEP carboxylating enzyme. . : , (d) Isocitrate cleavage enzyme ; lam : : -(e) An enzyme associated with favism : ee / Describe the factors which affect the rate of enzyme catalysed reactions. a “ The Henderson Hassalbalch equation is used to calculate the pH of a buffer solution. \ 4 @) Derive the equation from a hypothetical weak acid HA: [4 marks] : se det Bee joint in grams of acetic acid (CH;CO2H) and sodium acetate needed to : ” make one liter of a 50 mm acetate buffer with a pH of 5.0 (Ka of acetic acid = 1.9x10°, Na=23, C=12, O16, HI) : eal ee : a vant examples how eicosanoids diverse physiological functions have been at oe - Pagelofll . — on a ~id . - » - i e , ‘ Q <a RY Mecontuiee® § POE SYST . TEE Scanned by CamScanner Scanned by CamScanner ee Scanned by CamScanner ee Scanned by CamScanner ee Scanned by CamScanner Scanned by CamScanner Scanned by CamScanner Scanned by CamScanner \ 4 Scanned by CamScanner Scanned by CamScanner