Comprehensive Immunology Quiz — Antigen OmpathStudy

Continued from $1. Immunology Quiz - Formatted Questions and Answers Section 10: Antigen Processing and Presentation Question 1 The T cell-APC interaction is MHC -restricted, and the T cell-target cell interaction is MHC -restricted. Choices: a) CD4+; Class I; CD8+; Class II b) CD4+; Class II; CD8+; Class I c) CD8+; Class I; CD4+; Class II d) CD8+; Class II; CD4+; Class I Correct Answer: B Question 2.1 Which of the following describes where class I MHC is found and not where class II MHC is found? Choices: a) B cells b) Dendritic cells c) Macrophages d) Antigen presenting cells (A, B, & C) e) All nucleated cells Correct Answer: E Question 2.2 Peptides antigens generated in the cytosolic compartment (intracellular infection, e.g. virus) bind to MHC molecules for presentation to T cells. Peptide antigens generated in vesicles (extracellular infection, e.g. bacteria) bind to MHC molecules for presentation to T cells. Choices: a) Class I; CD4+; Class II; CD8+ b) Class II; CD4+; Class I; CD8+ c) Class I; CD8+; Class II; CD4+ d) Class II; CD8+; Class I; CD4+ Correct Answer: C Question 3.1 In the processing pathway for extracellular antigens, synthesis of MHC class II and invariant chain (li) occurs in the . Choices: a) Cytosol b) Golgi apparatus c) Endoplasmic reticulum d) Ribosomes e) Lysosomes Correct Answer: C Question 3.2 The invariant chain the empty peptide-binding groove. After vesicle fusion, the invariant chain is and peptides can enter the MHC class II grove. Choices: a) Activates; Added b) Activates; Degraded c) Blocks; Added d) Blocks; Degraded Correct Answer: D Question 4.1 In the processing pathway for intracellular antigens, the proteasome will viral protein molecules until peptides of residues are formed; these can bind to class I MHC molecules. Choices: a) Build; 8-11 b) Build; 9-30 c) Break down; 8-11 d) Break down; 9-30 Correct Answer: C Question 4.2 The transporter associated with antigen presentation (TAP) the peptides to traverse the membrane bilayer of the endoplasmic reticulum and bind in the empty peptide-binding groove of nascent MHC molecules being synthesized in the endoplasmic reticulum. Choices: a) Permits; Class I b) Permits; Class II c) Does not allow; Class I d) Does not allow; Class II Correct Answer: A Question 5 Mutations in TAP-1 or TAP-2 may alter the function of the heterodimer TAP. Which of the following is common for patients with TAP mutations? Choices: a) Human immuno-deficiency virus (HIV) infection b) Acquired immune deficiency syndrome (AIDS) c) Upper respiratory tract infections d) Coagulation disorders (hemophilia) e) Systemic inflammatory response syndrome (SIRS, sepsis) Correct Answer: C Question 6.1 Certain strains of adenovirus express a protein that inhibits the transcription of class I MHC molecules. What is a consequence of this? Choices: a) Reduced likelihood that peptides will be expressed at the cell surface b) Fewer peptides are available to bind to class I MHC c) Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes Correct Answer: C Question 6.2 A protein of herpes simplex virus (HSV) binds to TAP and inhibits peptide transport into the endoplasmic reticulum. What is a consequence of this? Choices: a) Reduced likelihood that peptides will be expressed at the cell surface b) Fewer peptides are available to bind to class I MHC c) Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes Correct Answer: B Question 6.3 Bacteria such as Mycobacterium tuberculosis have acquired the capacity to inhibit phagosome-lysosome fusion. What is a consequence of this? Choices: a) Reduced likelihood that peptides will be expressed at the cell surface b) Fewer peptides are available to bind to class I MHC c) Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes Correct Answer: A --- Section 11: Lymphocyte Activation Question 1.1 The structure of the B-cell receptor contains the invariant proteins Igα and Igβ, which are linked via and are essential for signal generation across the B-cell surface membrane and for surface expression of immunoglobulin receptors (mIgs). Choices: a) Covalent bonding b) Hydrophobic interactions c) Sulfide bonding d) Hydrogen bonding e) Peptide bonding Correct Answer: C Question 1.2 Immunoreceptor tyrosine-based activation motifs (ITAMs) are essential for signal transduction in cells. Choices: a) B cells b) T cells c) B cells or T cells d) B cells and T cells e) Neither B or T cells Correct Answer: D Question 1.3 Regarding the structure of the T-cell receptor, which of the following is NOT an invariant CD3 protein chain? Choices: a) Zeta (ζ) chain b) Epsilon (ε) chain c) Gamma (γ) chain d) Delta (δ) chain Correct Answer: A (Note: Zeta chain is part of CD3 complex, but delta chain refers to TCR delta, not CD3 delta) Question 2 Which of the following is the correct order for a lymphocyte to be activated? Choices: a) Recognition of antigen, activ