Oncopathology MCQs: Test Your Knowledge on OmpathStudy

Oncopathology MCQs --- Q1. Neoplasia a. Is the process of formation of new normal growths in the body b. Is any new abnormal and unregulated growth in the body – also called tumour c. Is a process of formation of tumours that stops after removal of inciting stimulus d. Is the process of formation of clonal tumours e. Includes growths from infections such as solid granulomas and cystic abscesses Answer: b This is the standard pathology definition. c is wrong because neoplastic growth persists even after the inciting stimulus is removed (unlike hyperplasia); e is wrong because granulomas/abscesses are inflammatory, not neoplastic. --- Q2. True of tumours a. Supportive stroma represents the proliferative component of tumours b. The parenchyma provides connective tissue framework for the tumour c. The stromal and parenchymal components of tumour do not influence each other d. The behaviour and pathologic consequences of a tumour depend on its parenchymal component e. The growth and evolution of a tumour depend on its parenchymal component Answer: d Parenchyma = the neoplastic cells themselves, which determine biologic behavior (benign/malignant, differentiation). Stroma (connective tissue + vessels) provides support and blood supply, which actually governs a tumor's growth/survival — not the parenchyma (making e false), and stroma/parenchyma interact closely (making c false). --- Q3. Which of the following is true regarding the nomenclature of tumours? a. Papillomas and papillary cystadenomas are synonyms for benign tumours with identical morphology b. Adenomas include benign glandular neoplasms and malignant polyps in general c. Some benign tumours are composed of undifferentiated cells and are termed poorly differentiated tumours d. Mature teratomas are benign teratogenous tumours derived from totipotential cells e. Immature teratomas are malignant mixed tumours derived from one germ cell layer Answer: d Mature (benign) teratomas arise from totipotential germ cells and differentiate into mature tissue from all three germ layers. "Poorly differentiated" is a malignant, not benign, descriptor; immature teratomas are malignant but still derive from all germ layers, not just one. --- Q4. Anaplasia is marked by the following morphological changes except? a. Pleomorphism b. Abnormal nuclear morphology c. High mitotic rate in supportive stroma d. Loss of polarity e. Formation of tumour giant cells Answer: c Anaplasia describes changes in the neoplastic (parenchymal) cells themselves — increased mitoses occur in tumor cells, not the stroma. --- Q5. In dysplasia a. There is uniformity of individual cells b. There is architectural orientation c. There is disordered growth d. There is increase in the number of cells in the tissue e. There is increase in the size of normal cells Answer: c Dysplasia = disordered, atypical epithelial growth with loss of normal architectural orientation and cellular uniformity — the opposite of a, b, and e (which describe normal/hyperplastic tissue). --- Q6. The following statements are false except? a. Haematogenous spread is exclusively seen in sarcomas b. Lymphatic spread is the least common pathway for dissemination of carcinomas c. Direct seeding of body cavities is the most common pathway of spread for sarcomas d. Nodal enlargement in proximity to a cancer is always due to metastasis e. Liver and lungs are most frequently involved in haematogenous spread of cancers Answer: e Liver and lungs receive the largest blood flow/filtration load and are classic sites of blood-borne metastasis. a/c/d are overgeneralized absolutes that are false (carcinomas also spread hematogenously; sarcomas spread mainly hematogenously not by seeding; reactive nodal enlargement can be non-metastatic). --- Q7. Which of the following is benign? a. Seminoma b. Meningioma c. Mesothelioma d. Melanoma e. None of the above Answer: b Meningioma is typically a benign tumor of meningeal (arachnoid cap) cells. The other four are all malignant. --- Q8. Which of the following is true of benign tumours? a. Most papillary cystadenomas are solid masses with finger-like projections on the surface b. Papillomas are projecting structures of fibro-vascular tissue supporting benign epithelial surface c. Benign tumours are less common than malignant tumours d. Benign tumours typically regress spontaneously e. When a benign tumour causes death via pressure effects it counted as a malignancy Answer: b This correctly describes papilloma histology. Cystadenomas are cystic, not solid (a false); benign tumors are actually more common than malignant ones overall; benign tumors don't typically regress; and a benign tumor causing death (e.g., a benign brain tumor causing herniation) remains histologically benign, not reclassified as malignant. --- Q9. Which of the following is not true of malignant tumours? a. Malignant change may occur secondary to an infection b. Malignant mesenchymal tumours are always anaplastic c. Most cells within ca