Cerebral Perfusion Pressure

Also written as CPP.

Perfusion is increased in the setting of hypoxia or (Adapted from Rosner MJ et al: Cerebral perfusion pressure:

What our notes say

• Perfusion is increased in the setting of hypoxia or (Adapted from Rosner MJ et al: Cerebral perfusion pressure: (Harrisons Pulmonary and Critical Care Medicine)
• Formula for cerebral perfusion pressure, with reference ranges (1 mark) (General Surgery CAT 2 (MBSG 4600): 4 October 2021)
• Administer high-volume crystalloids to maintain cerebral perfusion pressure (Shock and cardiovascular emergencies)
• $\rightarrow$ Marked rise in ICP $\rightarrow$ reduced cerebral perfusion pressure (CPP = MAP – ICP) $\rightarrow$ cerebral ischemia and herniation (Bacterial meningitis and encephalitis)
• Reduced cerebral perfusion pressure (CPP = MAP – ICP) → (Raised intracranial pressure)
• Circulation: Maintain MAP ≥ 65 mmHg (or SBP ≥ 90 mmHg) with isotonic fluids; avoid hypotension — Cerebral perfusion pressure = MAP – ICP; low MAP → ischemia (Raised intracranial pressure)

Study material on Cerebral Perfusion Pressure

• Harrisons Pulmonary and Critical Care Medicine
• Raised intracranial pressure

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