Delayed Hemolytic Transfusion Reaction
Also written as DHTR.
| Delayed hemolytic transfusion reaction (DHTR) | Fever, jaundice, falling Hb 3‑14 days post‑transfusion, positive indirect Coombs | Delayed onset, extravascular hemolysis, less severe renal impact. |
What our notes say
- | Delayed hemolytic transfusion reaction (DHTR) | Fever, jaundice, falling Hb 3‑14 days post‑transfusion, positive indirect Coombs | Delayed onset, extravascular hemolysis, less severe renal impact. | (Blood transfusion and reactions)
- | Delayed hemolytic transfusion reaction | Fever, jaundice, falling Hb 3‑14 days, positive indirect Coombs, no acute renal signs | Mild – asymptomatic fall in Hb; Moderate – symptomatic anemia, jaundice; Severe – renal impairment, severe anemia. | (Blood transfusion and reactions)
Study material on Delayed Hemolytic Transfusion Reaction
Practice questions on Delayed Hemolytic Transfusion Reaction
Which blood group system is most frequently associated with delayed hemolytic transfusion reactions that present with a rapid drop in hemoglobin but negative initial antibody screens?
- Kell
- Duffy
- Kidd
- MNS
Answer: C. The Kidd system is the classic cause of delayed hemolytic transfusion reactions. Antibodies fade quickly, screen negative, then surge after re-exposure causing rapid intravascular hemolysis.