Intravenous Immunoglobulin

Also written as IVIG.

Clostridium-specific intravenous immunoglobulin is of no benefit once spasm has started

What our notes say

Clostridium-specific intravenous immunoglobulin is of no benefit once spasm has started (Paediatrics end of fourth year main exam: 1 July 2019, Paper One, 99 of 100 MCQs)
*Answer*: Intravenous immunoglobulin (IVIG) – it is easier to administer, has comparable efficacy to plasma exchange, and avoids central line complications. (Peripheral neuropathy and Guillain-Barre syndrome)
Management: High-dose intravenous immunoglobulin (IVIG) is the treatment of choice. (Blood Transfusion Medicine: An Exam-Focused Review)
| Steroid‑refractory ITP | Intravenous immunoglobulin (IVIG) or anti‑D immunoglobulin | Rapid rise in platelets via Fc‑receptor blockade | (Thrombocytopenia and platelet disorders)
| Classic Guillain‑Barre (rapidly progressive ≤4 weeks) | Intravenous immunoglobulin (IVIG) – 2 days course | Monitor renal function, avoid volume overload | (Peripheral neuropathy and Guillain-Barre syndrome)
Chronic pure red cell aplasia in immunocompromised — IVIG (intravenous immunoglobulin); provides passive antibodies (EXAM: Bacteriophages, Laboratory Diagnosis, HPV & Parvovirus B19)