Lewy Bodies

Also written as DLB.

Pathology: loss of dopaminergic neurons, intracellular Lewy bodies (α-synuclein aggregates)

What our notes say

• Pathology: loss of dopaminergic neurons, intracellular Lewy bodies (α-synuclein aggregates) (Ovarian & Colorectal Cancer: Risks, Pathogenesis, Staging)
• | Lewy bodies | Single/multiple cytoplasmic eosinophilic inclusions · dense core + pale halo · composed of α-synuclein filaments | (Neurodegenerative Prion Diseases: CJD, Pathology & Rapid Dementia)
• > Spread pattern: Lewy bodies first in medulla → contiguous brainstem → limbic → neocortex *(consistent with prion-like spread)* (Neurodegenerative Prion Diseases: CJD, Pathology & Rapid Dementia)
• Protein Aggregation: Lewy bodies containing α-synuclein (MBMP2300: Medical Physiology II MCQs)
• Lewy bodies: Alpha-synuclein protein aggregates in remaining neurons (Medical Physiology II (Paper 2))

Study material on Lewy Bodies

• Neurodegenerative Prion Diseases: CJD, Pathology & Rapid Dementia

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