Peptic Ulcer Disease
Also written as PUD.
Peptic Ulcer Disease — gastric or duodenal ulcers; caused by H. pylori or NSAIDs
What our notes say
- Peptic Ulcer Disease — gastric or duodenal ulcers; caused by H. pylori or NSAIDs (CRUSH COURSE (PART 2) Clinical Chem Patho)
- c) Explain why indiscriminate use of NSAIDs is contraindicated among Peptic Ulcer Disease patients (5 Marks) (Medical Physiology Section A - Complete Questions and Comprehensive Answers)
- Topics tested: HIV-related mouth, oesophageal and bowel disease, hepatitis B and C, non-alcoholic fatty liver disease, portal hypertension and varices, liver function tests, acute pancreatitis, cholera, peptic ulcer disease, and causes of rectal bleeding. (Internal Medicine 4th Year 1st Semester CAT: HIV and the gut, liver disease and )
- The hypercalcemia leads to increased gastrin production and peptic ulcer disease. (Chemical pathology and Endocrine pathology — Past Paper Questions & Answers)
- Peptic Ulcer Disease: Aetiology, Pathogenesis, Complications (Ovarian & Colorectal Cancer: Risks, Pathogenesis, Staging)
- Complications: peptic ulcer disease, MALT lymphoma (chronic antigenic stimulation of mucosal lymphoid tissue), intestinal metaplasia → increased gastric adenocarcinoma risk (Ovarian & Colorectal Cancer: Risks, Pathogenesis, Staging)
Study material on Peptic Ulcer Disease
- GASTROINTESTINAL PATHOLOGY (Part 1)
- MCQ: GASTROINTESTINAL PATHOLOGY — 60 MCQs (Redistributed Answers)
Practice questions on Peptic Ulcer Disease
A 55-year-old male with a history of peptic ulcer disease presents with sudden onset of severe upper abdominal pain that radiates to the back, and he is hypotensive and rigid. What is the most likely diagnosis?
- Acute pancreatitis
- Bowel obstruction
- Perforated peptic ulcer
- Mesenteric ischemia
Answer: C. Sudden onset of severe upper abdominal pain, rigidity, and hypotension in a patient with peptic ulcer disease strongly suggests a perforated peptic ulcer, a surgical emergency. ---
A 60-year-old male with a history of H. pylori infection and peptic ulcer disease undergoes an upper endoscopy. Biopsy of a gastric ulcer shows intestinal metaplasia and dysplasia. What is the most concerning implication of this finding?
- Increased risk of gastric lymphoma
- Increased risk of gastric adenocarcinoma
- Increased risk of Zollinger-Ellison syndrome
- Increased risk of Helicobacter pylori reinfection
Answer: B. Intestinal metaplasia and dysplasia in a gastric ulcer, especially in the context of H. pylori infection, are significant risk factors for the development of gastric adenocarcinoma. ---