Inflammatory Bowel Disease
Also written as IBD.
One of the extraintestinal manifestations of this form of inflammatory bowel disease is hepatic sclerosing cholangitis, which can still occur even after the colon is removed.
What our notes say
- One of the extraintestinal manifestations of this form of inflammatory bowel disease is hepatic sclerosing cholangitis, which can still occur even after the colon is removed. (Gastrointestinal and liver — Past Paper Questions & Answers)
- At his age, this is likely a sporadic type of colon cancer, not an inherited condition nor a complication of inflammatory bowel disease, particularly in view of no past history of bowel disease. (Gastrointestinal and liver — Past Paper Questions & Answers)
- | Inflammatory and autoimmune | Rheumatoid arthritis, inflammatory bowel disease, Sjögren's | (Bronchiectasis)
- Medical: age over 60, obesity, heart failure, nephrotic syndrome, inflammatory bowel disease, HIV, TB, polycythaemia, antiphospholipid syndrome. (DVT and Venous Thromboembolism (with Pulmonary Embolism))
- Risk factors: advanced HIV (CD4 below 50), organ transplant and immunosuppressive drugs, chemotherapy, steroids, inflammatory bowel disease, critical illness and diabetes. (Internal Medicine CAT 1 (MBIM 6112), 2019/2020: gastroenterology and hepatology,)
- Inflammatory bowel disease (ulcerative colitis, Crohn's). (Internal Medicine 4th Year 1st Semester CAT: HIV and the gut, liver disease and )
Study material on Inflammatory Bowel Disease
- GASTROINTESTINAL PATHOLOGY (Part 2)
- Gastrointestinal and liver
- pathology essays
- systemic pathology essays
- MCQ: GASTROINTESTINAL PATHOLOGY — 60 MCQs (Redistributed Answers)
Practice questions on Inflammatory Bowel Disease
ATG16L1 polymorphisms are associated with inflammatory bowel disease because this gene:
- Encodes a cytokine receptor
- Regulates tight junction proteins
- Is required for autophagosome formation
- Controls bacterial translocation directly
Answer: C. ATG16L1 is one of the autophagy-related genes (Atgs) required for autophagosome formation. Defective autophagy impairs clearance of intracellular bacteria and stress responses in intestinal cells, contributing to inflammation. This links autophagy to inflammatory bowel disease pathogenesis. ## SECTION 5: OXIDATIVE STRESS & FREE RADICALS ---
A 20-year-old female with a history of irritable bowel syndrome (IBS) develops new onset of inflammatory bowel disease (IBD). Which symptom is most indicative of IBD over IBS?
- Abdominal pain relieved by defecation
- Bloating
- Rectal bleeding
- Intermittent constipation
Answer: C. Rectal bleeding is a hallmark symptom that differentiates inflammatory bowel disease (like ulcerative colitis) from irritable bowel syndrome, which typically does not involve bleeding. ---
Persons with inflammatory bowel disease have ulcerating bowel lesions with a TH17 immune response extending over decades. Which cell type is mediating the tissue injury?
- B lymphocytes
- Dendritic cells
- NK cells
- T lymphocytes
Answer: D. TH17 is a subset of helper T lymphocytes that produce IL-17, promoting neutrophil recruitment and chronic mucosal inflammation. T lymphocytes are the primary mediators in this cell-mediated (type IV) chronic inflammatory bowel response. ---