Superoxide Dismutase
Also written as SOD.
| SOD1 (chr 21) | ~20% familial ALS · copper-zinc superoxide dismutase · NOT loss of free radical detoxification → gain-of-function · mutant SOD1 misfolds + aggregates → proteasomal/autophagic dysfunction · axonal transport disruption · mitochondrial injury · → apoptosis |
What our notes say
- | SOD1 (chr 21) | ~20% familial ALS · copper-zinc superoxide dismutase · NOT loss of free radical detoxification → gain-of-function · mutant SOD1 misfolds + aggregates → proteasomal/autophagic dysfunction · axonal transport disruption · mitochondrial injury · → apoptosis | (Neurodegenerative Prion Diseases: CJD, Pathology & Rapid Dementia — Notes)
- Function: Cofactor for oxidase enzymes, iron metabolism (ceruloplasmin), collagen cross-linking, melanin formation, antioxidant (superoxide dismutase) (Chemical Pathology Practice Examination: Essays — Past Paper)
- Superoxide dismutase (SOD) converts superoxide anion to: (Pathology MCQs: Cell Injury, Cell Death, and Adaptations — MCQ Bank)