Systemic Inflammatory Response

Also written as SIRS.

If unchecked: Septic cascade → Systemic inflammatory response syndrome (SIRS) → Hypotension, organ dysfunction → Septic shock.

What our notes say

• If unchecked: Septic cascade → Systemic inflammatory response syndrome (SIRS) → Hypotension, organ dysfunction → Septic shock. (Pneumonia)
• | Systemic inflammatory response – cytokines (IL‑8, TNF‑α) and acute‑phase reactants | Persistent systemic inflammation contributes to weight loss, anemia and, in severe cases, secondary amyloidosis. | (Bronchiectasis)
• Systemic inflammatory response (release of cytokines, inflammatory mediators) (Pulmonary oedema and ARDS)
• | Full blood count | Assesses systemic inflammatory response | Normocytic anemia, marked neutrophil leukocytosis | (Infective endocarditis)
• Pyrogen release (TNF-alpha, IL-1, IL-6) from infected macrophages causing systemic inflammatory response and relative bradycardia (Enteric fever)
• Systemic inflammatory response (SIRS) criteria: Fever/hypothermia, tachycardia, tachypnoea, leukocytosis/leukopenia. (Common fungal and parasitic infections)

Related topics

• Systemic Inflammatory Response Syndrome
• Septic Shock
• Complications and Prognosis
• Acute Kidney Injury
• Differential Diagnosis
• Septic Arthritis
• Vital Signs
• Compartment Syndrome
• Sickle Cell Disease
• Inflammation