Systemic Inflammatory Response Syndrome

Also written as SIRS.

If unchecked: Septic cascade → Systemic inflammatory response syndrome (SIRS) → Hypotension, organ dysfunction → Septic shock.

What our notes say

• If unchecked: Septic cascade → Systemic inflammatory response syndrome (SIRS) → Hypotension, organ dysfunction → Septic shock. (Pneumonia)
• Systemic effects: fever (mediated by IL-1/IL-6/TNF acting on the hypothalamus), leukocytosis, elevated acute-phase proteins (CRP, fibrinogen), tachycardia, and in severe cases systemic inflammatory response syndrome/sepsis. (Eoy paper 2 gen systemic Patho 2025 — Past Paper Questions & Answers)

Related topics

• Systemic Inflammatory Response
• Neoplasia
• Pleural Effusion
• Lung Cancer
• Diabetes Mellitus
• Stroke
• Insulin
• Oedema
• Inflammation
• Sepsis