Transfusion-Related Acute Lung Injury

Q: TRALI (Transfusion-Related Acute Lung Injury) is characterised by which clinical picture?

Urticaria and bronchospasm within 15 minutes. TRALI is characterized by acute respiratory distress, severe hypoxia, and non-cardiogenic pulmonary oedema occurring within 6 hours of transfusion.

Also written as TRALI.

TRALI (Transfusion-Related Acute Lung Injury): within 6 hours; pulmonary infiltrates with chest symptoms; caused by HLA antibodies in donor plasma (multiparous women); management supportive; male donors preferred to reduce risk

What our notes say

TRALI (Transfusion-Related Acute Lung Injury): within 6 hours; pulmonary infiltrates with chest symptoms; caused by HLA antibodies in donor plasma (multiparous women); management supportive; male donors preferred to reduce risk ( Transfusion: Governance, Donor Selection & Blood Groups)
*(Others acceptable: high altitude, near-drowning, drug overdose/reaction, transfusion-related acute lung injury (TRALI), radiation injury)* (End Sem Cat: Respiratory Pathology: Emphysema, ARDS, Pneumoconiosis)
| Feature | Transfusion-Associated Circulatory Overload (TACO) | Transfusion-Related Acute Lung Injury (TRALI) | (Blood Transfusion Medicine: An Exam-Focused Review)

Study material on Transfusion-Related Acute Lung Injury

Practice questions on Transfusion-Related Acute Lung Injury

TRALI (Transfusion-Related Acute Lung Injury) is characterised by which clinical picture?

Urticaria and bronchospasm within 15 minutes
Acute hypoxia, non-cardiogenic pulmonary oedema within 6 hours of transfusion
Bilateral leg oedema and raised JVP
Haemolytic anaemia with a positive DAT
Fever and chills without other symptoms ✅ Answer: B

Answer: A. TRALI is characterized by acute respiratory distress, severe hypoxia, and non-cardiogenic pulmonary oedema occurring within 6 hours of transfusion.