Antidiuretic Hormone
Also written as ADH.
Arginine vasopression, or antidiuretic hormone (ADH) is made in the hypothalamus and then stored and released from the posterior pituitary.
Antidiuretic hormone (ADH):
- A. Is stored in the anterior pituitary gland
- B. Release is stimulated by hypernatraemia
- C. Release is inhibited by hypotension
- D. Release is inhibited by mannitol
- E. Leads to water reabsorption by increasing water permeability of the ascending loop of Henle
Read this in Paediatrics end of fourth year special supplementary exam: August 2019, Paper On
Antidiuretic Hormone (ADH / Vasopressin)
- Synthesis Location: Primarily synthesized in the supraoptic nucleus of the hypothalamus.
- Function: The primary role of ADH is to increase water reabsorption in the renal collecting ducts and distal convoluted tubules by inserting aquaporin-2 channels into the apical membrane, thereby concentrating urine and conserving body wate
- Regulation: Released in response to increased plasma osmolality (detected by osmoreceptors in the hypothalamus) and decreased blood volume/pressure (detected by baroreceptors).
- Clinical Relevance: Deficiency of ADH leads to central Diabetes Insipidus , characterized by polyuria (excessive urination) and polydipsia (excessive thirst). Excessive ADH secretion leads to the Syndrome of Inappropriate ADH Secretion (SIA
Read this in Hypothalamic Hormones: Master Regulators of the Endocrine System
What our notes say
- Arginine vasopression, or antidiuretic hormone (ADH) is made in the hypothalamus and then stored and released from the posterior pituitary. (Chemical pathology and Endocrine pathology — Past Paper Questions & Answers)
- Which of the following is a function of antidiuretic hormone (ADH)?A) It decreases blood volume (Endocrine and Metabolic Pathology MCQs for Medical Students)
- Its permeability to water is tightly controlled by Antidiuretic Hormone (ADH), allowing for variable water reabsorption based on the body's hydration status. (Renal Anatomy and Physiology)
- Central masses with the syndrome of inappropriate antidiuretic hormone secretion point to small-cell lung cancer, a neuroendocrine tumour linked to smoking that spreads early. (Respiratory Medicine Question Bank: 15 Clinical MCQs)
- Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH) secondary to ectopic ADH production by lung carcinoma (paraneoplastic syndrome). (Chemical Pathology Sem 1)
- Antidiuretic Hormone (ADH/Vasopressin): Water conservation and blood pressure regulation (Medical Physiology Paper II MCQs)
Study material on Antidiuretic Hormone
- Endocrine and Metabolic Pathology MCQs for Medical Students
- Medical Physiology Year Two – Paper Two MCQs
- Hypothalamic Hormones: Master Regulators of the Endocrine System
- Liver Function Tests (LFTs)
- Chemical Pathology Sem 1
- Chemical Pathology Practice Examination
- Medical Physiology Paper II MCQs
- Renal Anatomy and Physiology
- Chemical pathology and Endocrine pathology
- Medical Physiology Pp2 Year 2