Bartter'S Syndrome
depletion results in intracellular acidification and an Mineralocorticoid Vomiting\nexcess Bartter's syndrome
Bartter’s Syndrome
- Features : Failure to thrive (FTT), polyuria, nephrocalcinosis, short stature, mental retardation.
- Electrolyte Imbalance : Hypokalaemic metabolic alkalosis, renal salt wasting, nephrogenic diabetes insipidus, hypercalciuria.
- Cause : Sporadic or autosomal recessive (AR) mutation.
- Pathophysiology :Overactivation of the renin-angiotensin-aldosterone system and hyperplasia of the juxtaglomerular apparatus .
- Increased production of prostaglandin E2 in the kidney.
Read this in Liver Function Tests (LFTs) — Notes
Bartter's Syndrome
- Features : FTT, polyuria, hypokalemia, alkalosis
- Mechanism : Defective mTAL transport (NKCCT, ROMK1, CLCKB)
Read this in KIDNEY FUNCTION TESTS & GASTRIC FUNCTION — Notes
What our notes say
- depletion results in intracellular acidification and an Mineralocorticoid Vomiting\nexcess Bartter's syndrome (Harrisons Pulmonary and Critical Care Medicine)
- Bartter’s syndrome (loss of function mutations\nin TALH) Chronic administration of alkali to individuals with nor 9. (Harrisons Pulmonary and Critical Care Medicine)