Gitelman'S Syndrome
\n\nTABLE 40-6 be attributable to Bartter’s or Gitelman’s syndrome, 419\nCAUSES OF METABOLIC ALKALOSIS magnesium deficiency, vomiting, exogenous alkali, or\ndiuretic ingestion.
Gitelman’s Syndrome
- Features : Hypokalaemic metabolic alkalosis, hypocalciuria , and hypomagnesaemia .
- Inheritance : Sporadic or autosomal recessive (AR).
- Presentation : Late childhood or early adulthood.
- Pathophysiology :Defect in the thiazide-sensitive Na-Cl cotransporter (NCCT) in the distal convoluted tubule .
- Similar effects to chronic thiazide diuretic use.
Read this in Liver Function Tests (LFTs) — Notes
Gitelman's Syndrome
- Features : Like Bartter's + hypocalciuria + hypomagnesemia
- Mechanism : Defective DCT NCCT
- Effect : Like thiazide diuretics
Read this in KIDNEY FUNCTION TESTS & GASTRIC FUNCTION — Notes
What our notes say
- \n\nTABLE 40-6 be attributable to Bartter’s or Gitelman’s syndrome, 419\nCAUSES OF METABOLIC ALKALOSIS magnesium deficiency, vomiting, exogenous alkali, or\ndiuretic ingestion. (Harrisons Pulmonary and Critical Care Medicine)
- Renal origin magnesium deficiency, Bartter’s or Gitelman’s syndrome,\n1. (Harrisons Pulmonary and Critical Care Medicine)