Nephrogenic Diabetes Insipidus

Also written as NDI.

Nephrogenic Diabetes Insipidus results from the kidneys' inability to respond to ADH.

What our notes say

Nephrogenic Diabetes Insipidus results from the kidneys' inability to respond to ADH. (Hypothalamic Hormones: Endocrine Regulation and Functions — Notes)
Side effects: tremor, thirst and polyuria (nephrogenic diabetes insipidus), weight gain, hypothyroidism, hypercalcaemia (hyperparathyroidism), GI upset, chronic kidney disease. (Bipolar and Related Disorders)
Hypercalcaemia → ↑ ionised Ca²⁺ → decreased neuronal excitability → polyuria, nephrogenic diabetes insipidus, renal calculi; shortened QT. (Sodium, potassium and calcium disorders)
Peripheral edema: Hypervolemic hyponatraemia (e.g., heart failure, cirrhosis) or hyper‑calcaemia‑induced nephrogenic diabetes insipidus causing polyuria then volume overload. (Sodium, potassium and calcium disorders)
(acquired nephrogenic diabetes insipidus), causing polyuria and (Davidson's Essentials of Medicine - 2nd)
\n• Excess fluid intake\n• Hyperglycaemia\n• Cranial diabetes insipidus\n• Nephrogenic diabetes insipidus:\nLithium, diuretics\nInterstitial nephritis\nHypokalaemia, hypercalcaemia\n\n KIDNEY AND URINARY TRACT DISEASE • 7 (Davidson's Essentials of Medicine - 2nd)