Cl Cotransporter

Also written as NCCT.

(a) Furosemide in CHF: a loop diuretic that blocks the Na-K-2Cl cotransporter in the thick ascending limb, causing natriuresis.

What our notes say

• (a) Furosemide in CHF: a loop diuretic that blocks the Na-K-2Cl cotransporter in the thick ascending limb, causing natriuresis. (Clinical Pharmacology I (MBPL 4400) main exam: 25 January 2023)
• Thiazide diuretics inhibit the Na-Cl cotransporter in the distal convoluted tubule, causing: (Chemical Pathology Sem 1)
• NCCT transporter: Thiazide-sensitive Na+/Cl⁻ cotransporter (Medical Physiology Section A - Complete Questions and Comprehensive Answers)
• Key Mutations:NKCC2 (Na-K-Cl cotransporter): Impaired NaCl reabsorption → salt wasting, diuresis, kaliuresis, hypercalciuria. (Liver Function Tests (LFTs))
• Pathophysiology:Defect in the thiazide-sensitive Na-Cl cotransporter (NCCT) in the distal convoluted tubule. (Liver Function Tests (LFTs))

Study material on Cl Cotransporter

• Medical Physiology Section A - Complete Questions and Comprehensive Answers
• Medical Physiology Paper II MCQs
• Liver Function Tests (LFTs)

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