Bilirubin Metabolism

Bilirubin Metabolism: Bilirubin is a breakdown product of heme, released from hemoglobin in aged red blood cells.

What our notes say

Bilirubin Metabolism: Bilirubin is a breakdown product of heme, released from hemoglobin in aged red blood cells. (CLINICAL BIOCHEMISTRY LAQs & SAQs)
Exocrine secretion: The liver also secretes externally into the digestive tract, primarily through the production of bile, which is a terminal product of detoxification processes, including bilirubin metabolism. (The Heme and Liver)
Bilirubin metabolism in the liver: Once free bilirubin is taken up by hepatocytes, it undergoes conjugation with glucuronic acid, forming conjugated bilirubin, which is more polar and water-soluble. (The Heme and Liver)
BILIRUBIN METABOLISM DISORDERS (recap from Chemical Pathology — relevant here too)- Crigler-Najjar type II — reduced UGT activity (Cardiovascular, Respiratory & GI/Hepatobiliary Pathology Revision (MBPA 3500 Pap)
Hepatic (Hepatocellular) Jaundice:Dysfunction of hepatocytes affecting bilirubin metabolism (Chemical Pathology Practice Examination)
Bilirubin Metabolism:Heme → Biliverdin → Bilirubin → Conjugated in liver → Excreted as bile. (CLINICAL BIOCHEMISTRY LAQs & SAQs)