Alcohol Dehydrogenase
Also written as ADH.
One could treat methanol poisoning with ethanol and/or fomepizole which are competitive inhibitors because they are metabolized via the same alcohol dehydrogenase as methanol.
What our notes say
- One could treat methanol poisoning with ethanol and/or fomepizole which are competitive inhibitors because they are metabolized via the same alcohol dehydrogenase as methanol. (CNS PATHOLOGY — Past Paper Questions & Answers)
- Methanol Metabolism in the Liver:Methanol is oxidized by alcohol dehydrogenase (ADH) into formaldehyde, which is then rapidly converted by aldehyde dehydrogenase (ALDH) into formic acid, the primary toxic agent. (CLINICAL BIOCHEMISTRY LAQs & SAQs)
- Biochemical Reactions:Methanol → Formaldehyde*(Enzyme: Alcohol Dehydrogenase)* (CLINICAL BIOCHEMISTRY LAQs & SAQs)
- Alcohol dehydrogenase (ADH) pathway:Converts ethanol to acetaldehyde in the cytosol of liver cells. (Integrated Tissue Metabolism -LAQs and SAQs)
- Alcohol dehydrogenase (ADH) – Converts ethanol to acetaldehyde in the cytosol. (Integrated Tissue Metabolism -LAQs and SAQs)
- Generation of excess NADH by alcohol dehydrogenase + acetaldehyde dehydrogenase → ↑ lipid biosynthesis 2. (Liver Histology & Physiology)