Pyruvate Dehydrogenase
Also written as PDH.
Pyruvate enters pyruvate dehydrogenase complex, converting it to acetyl-CoA.
What our notes say
- Pyruvate enters pyruvate dehydrogenase complex, converting it to acetyl-CoA. (Principles of Medical Microbiology and Parasitology LAQs & SAQs)
- Autoantibody: - Anti-mitochondrial Ab in >90% of patients ⭐ - Target: mitochondrial pyruvate dehydrogenase ⭐ (Liver Histology & Physiology)
Study material on Pyruvate Dehydrogenase
Practice questions on Pyruvate Dehydrogenase
In the pyruvate dehydrogenase reaction, which of the following statements is INCORRECT?
- E3 dehydrogenates reduced form of lipoate (reoxidation)
- The reaction takes place in the cytosol
- E2 transfers an acetyl group and a H atom
- Lipoate may be synthesized by the body and is not therefore essential
- E1 loads an acetyl group and a H atom to the oxidized form of lipoate ✅ Answer: B. The reaction takes place in the cytosol
Answer: A. This is the incorrect statement (as asked): the pyruvate dehydrogenase complex reaction occurs in the mitochondrial matrix, not the cytosol. ---
Regulation of muscle pyruvate dehydrogenase (PDH) during starvation ---
- Fully activated in early starvation, then switched off
- Becomes more dephosphorylated as starvation progresses
- PDH kinase is activated in the first 48h and stays active
- PDH phosphatase becomes more active over time
- PDH becomes more active over time
Answer: C.