Pentose Phosphate Pathway
Also written as PPP.
The NADPH produced during the Pentose Phosphate Pathway, rather than NADH, is useful for:
What our notes say
- The NADPH produced during the Pentose Phosphate Pathway, rather than NADH, is useful for: (Medical Physiology End of Semester 1 Exam — March 2019 (Past Paper))
- The pentose phosphate pathway (PPP) is a cytosolic pathway that is active in the following tissues/cells EXCEPT in the: (Biochemistry I End of Year MCQs — September 2020 (Past Paper))
- When acetate is the sole source of carbon for some microorganisms, the cycle used is called:A) Pentose phosphate pathway (Molecular Biology,Molecular Genetics & Microbial-Biochemistry MCQs)
- Hexose Monophosphate Shunt (Pentose Phosphate Pathway):This pathway is crucial for generating NADPH, which is important for maintaining the integrity of the erythrocyte membrane and protecting against oxidative damage. (Blood Biochemistry)
- The hexose monophosphate shunt (HMP shunt), also known as the pentose phosphate pathway (PPP), is another crucial metabolic pathway in red blood cells that operates alongside glycolysis. (Blood Biochemistry)
- Describe the benefits of pentose phosphate pathway to a cell. (Medical Physiology Assorted SAQs — With Answers (Past Paper Study Guide))
Study material on Pentose Phosphate Pathway
- CLINICAL BIOCHEMISTRY LAQs & SAQs
- Blood Biochemistry
- Integrated Tissue Metabolism MCQs
- Medical Physiology Mid-Semester Exam — November 2019 (Past Paper)
Practice questions on Pentose Phosphate Pathway
The Pentose Phosphate Pathway in RBCs is essential for generating:
- ATP
- NADPH
- FADH2
- Glucose
Answer: B. NADPH is required to maintain reduced glutathione, which protects the RBC from oxidative stress.
In the erythrocyte, the Pentose Phosphate Pathway is the sole source of:
- ATP
- NADH
- NADPH
- FADH2
Answer: C. Because RBCs lack mitochondria, the PPP (HMP shunt) is their only source of NADPH, which is needed to keep glutathione reduced.
Which statement best describes the relationship between the pentose phosphate pathway (PPP) and lipogenesis? ---
- The PPP produces glycerol for esterification of newly formed fatty acids
- Lipogenesis provides glycerol phosphate for the PPP
- Lipogenesis uses NADPH produced by the PPP
- The PPP provides ATP to fuel lipogenesis
- The PPP provides carbon dioxide to produce malonyl-CoA
Answer: C.
The oxidation of 3 mol of glucose by the pentose phosphate pathway may result in the production of ---
- 2 mol of pentose, 4 mol of NADPH and 8 mol of $\text{CO}_2$
- 3 mol of pentose, 4 mol of NADPH and 3 mol of $\text{CO}_2$
- 3 mol of pentose, 6 mol of NADPH and 3 mol of $\text{CO}_2$
- 4 mol of pentose, 3 mol of NADPH and 3 mol of $\text{CO}_2$
- 4 mol of pentose, 6 mol of NADPH and 3 mol of $\text{CO}_2$
Answer: A.
The NADPH produced during the Pentose Phosphate Pathway rather than NADH is useful for ---
- Increasing activity of free Oxygen radicals in the mitochondria
- Synthesizing essential amino acids
- Synthesizing fatty acids
- Direct generation of energy when oxidized in the cell
- Catalyzing water formation in the matrix.
Answer: A.
All the following except one are advantages of the Pentose Phosphate Pathway in glucose metabolism to produce ATP. Select the one ---
- It takes place in both cytoplasm and mitochondria allowing more space
- It continues at normal rate even in anaerobic conditions
- The NADPH it yields rather than NADH can be used to synthesize fatty acid chains from acetyl co-A of glucose origin
- It yields Pentose Phosphates that can be used to synthesize nucleotides and diphosphoglycerates
- Provides NADPH which takes part in antioxidant process
Answer: A.