Pyruvate Kinase
Also written as PK.
Pyruvate kinase (PK) deficiency — causing chronic haemolytic anaemia
What our notes say
- Pyruvate kinase (PK) deficiency — causing chronic haemolytic anaemia (Haematopathology MCQs: Blood Disorders & Anemia Explained)
- Pyruvate kinase — causing accumulation of 2,3-DPG and membrane rigidity (Haematopathology MCQs: Blood Disorders & Anemia Explained)
- Occurs in patients with: sickle cell disease, hereditary spherocytosis, thalassaemia, G6PD deficiency, pyruvate kinase deficiency, autoimmune haemolytic anaemia (EXAM: Bacteriophages, Laboratory Diagnosis, HPV & Parvovirus B19)
Practice questions on Pyruvate Kinase
Which drug targets the vicynyl sulfhydryl groups of pyruvate kinase? ---
- Pyrimethamine
- Sulfadiazine
- Meglumine antimonate
- Melarsoprol
- Sulfadoxine
Answer: D.