Microangiopathic Haemolytic Anaemia
Also written as MAHA.
HUS gives a Coombs-negative microangiopathic haemolytic anaemia with thrombocytopenia and kidney injury.
What our notes say
- HUS gives a Coombs-negative microangiopathic haemolytic anaemia with thrombocytopenia and kidney injury. (Internal Medicine CAT 1 (MBIM 6112), 2019/2020: gastroenterology and hepatology,)
- Pentad: thrombocytopenia, microangiopathic haemolytic anaemia (schistocytes), fever, renal impairment, neurological symptoms (Renal, Liver, Cardiac & Adrenal Function Tests for Year 3)
- Microangiopathic haemolytic anaemia — fibrin strands shearing red cells in small vessels (Haematopathology MCQs: Blood Disorders & Anemia Explained)
- Increased destruction (haemolytic) — hereditary (sickle cell disease, thalassaemia, hereditary spherocytosis, G6PD deficiency) or acquired (autoimmune haemolytic anaemia, malaria, microangiopathic haemolytic anaemia/DIC) (Year 3: Haematology and Blood Transfusion Pathology)
- Red cells traumatised passing through fibrin-narrowed vessels → microangiopathic haemolytic anaemia (Hematologic Malignancies and Bleeding Disorders)
- Microangiopathic haemolytic anaemia (MAHA) — schistocytes on blood film (Platelet Disorders)