Hepatorenal Syndrome

Hepatorenal Syndrome: Renal failure secondary to severe liver disease without intrinsic kidney pathology; characterized by low urinary sodium.

HEPATORENAL SYNDROME

Renal failure in severe liver disease WITHOUT intrinsic kidney disease - Excluded: concomitant liver + kidney damage, ATN secondary to circulatory collapse - Pathogenesis: vasoconstriction → decreased renal blood flow - Urine : hyperosmolar

Renal failure in severe liver disease WITHOUT intrinsic kidney disease - Excluded: concomitant liver + kidney damage, ATN secondary to circulatory collapse - Pathogenesis: vasoconstriction → decreased renal blood flow - Urine : hyperosmolar

Hepatorenal Syndrome: Renal failure secondary to severe liver disease without intrinsic kidney pathology; characterized by low urinary sodium. (Liver Histology, Physiology and Pathology)
c) Associated with a significant decrease in the risk of developing hepatorenal syndrome (Internal Medicine CAT 1 (MBIM 6112), 2019/2020: gastroenterology and hepatology,)
Pentoxifylline (a TNF inhibitor) lowers the risk of hepatorenal syndrome in severe alcoholic hepatitis. (Internal Medicine CAT 1 (MBIM 6112), 2019/2020: gastroenterology and hepatology,)
Reduced renal perfusion: hepatorenal syndrome, NSAIDs and ACE inhibitors or ARBs, renal artery stenosis. (Junior Clerkship in Internal Medicine (MBIM4100) main exam, Paper One: 31 Januar)
Life-threatening complications: - Hepatic failure → multiple organ failure - Coagulopathy - Hepatic encephalopathy - Hepatorenal syndrome - Esophageal varices → rupture → massive GI bleed - Hepatocellular carcinoma (Liver Histology & Physiology)