Bone Marrow Transplantation
Also written as BOOP, BMT.
Treatment:\n● Glucocorticoids (prednisone) are the usual initial therapy, but many patients do not respond.\n● Bone marrow transplantation.
What our notes say
- Treatment:\n● Glucocorticoids (prednisone) are the usual initial therapy, but many patients do not respond.\n● Bone marrow transplantation. (Anemia)
- Also successful bone marrow transplantation has is a defect or deficiency of osteoclasts or their precursors (Devendra K. Gupta, Krishna M. Goel - Hutchison’s Paediatrics. chdhe-Jaypee Broth)
- It is now possible to cure some infants with the severe\nform of the disease by bone marrow transplantation from (Devendra K. Gupta, Krishna M. Goel - Hutchison’s Paediatrics. chdhe-Jaypee Broth)
- Haemopoietic stem cell (bone marrow) transplantation, especially for younger patients with a matched donor. (Internal Medicine CAT 1 (MBChB 4), 2022: liver, pancreas and bone marrow, 30 MCQ)
- See Bone marrow transplantation (BOOP), HP and, 82\nICP and, 357 BNP. (Harrisons Pulmonary and Critical Care Medicine)
- See Beryllium lymphocyte proliferation and, 466 bronchiectasis and, 169\ntesting Bone marrow transplantation (BMT), 85, 486, 489 COPD and, 186 (Harrisons Pulmonary and Critical Care Medicine)
Study material on Bone Marrow Transplantation
- Harrisons Pulmonary and Critical Care Medicine
- BABY NELSON PEADS
- Devendra K. Gupta, Krishna M. Goel - Hutchison’s Paediatrics. chdhe-Jaypee Brothers (2012)
- Liver Histology and Physiology: Structural Units and Acinar Zones — Notes
- Anemia
Practice questions on Bone Marrow Transplantation
A 50-year-old immunocompromised man receives non-irradiated blood products after bone marrow transplantation. Two weeks later he develops an extensive skin rash, profuse diarrhea, rising liver enzymes, and severe pancytopenia. Most likely diagnosis?
- Graft-versus-host disease from transfusion
- Acute hemolytic transfusion reaction
- Delayed hemolytic transfusion reaction
- Cytomegalovirus infection from transfusion
Answer: A. Immunocompromised patient + non-irradiated blood + skin rash + diarrhea + liver dysfunction + pancytopenia = transfusion-associated graft-versus-host disease. Donor lymphocytes engraft and attack host tissues. Prevented by irradiating blood products for immunocompromised recipients.