Cervical Intraepithelial Neoplasia
Also written as CIN.
A biopsy of the cervix is performed, and on microscopic examination shows cervical intraepithelial neoplasia III (CIN III).
What our notes say
- A biopsy of the cervix is performed, and on microscopic examination shows cervical intraepithelial neoplasia III (CIN III). (Female system — Past Paper Questions & Answers)
- CIN = Cervical Intraepithelial Neoplasia; koilocytes are hallmark HPV-infected cells (General & Systemic Pathology SAQ — Paper II)
- Which grading system is used for cervical intraepithelial neoplasia (CIN), and what do these grades correspond to in terms of squamous intraepithelial lesions? → CIN I, II, III correspond to LSIL (CIN I) and HSIL (CIN II and III). (Outline of Female Reproductive Pathology)
- Regarding premalignant conditions of the cervix (cervical intraepithelial neoplasia, CIN), identify the false statement. (Year 4 Gynaecology CAT (MBOG 4212): 15 March 2019, 39 of 40 MCQs)
- Pathogenesis: HPV E6 protein degrades p53 and E7 protein inactivates Rb, disabling key tumour-suppressor checkpoints; this drives progression through cervical intraepithelial neoplasia (CIN I to II to III) to invasive carcinoma, typically at the transformation zone. (Eoy paper 2 gen systemic Patho 2025 — Past Paper Questions & Answers)
- The combined loss of p53 and Rb function permits accumulation of genetic damage and progression through cervical intraepithelial neoplasia (CIN I → II → III) to invasive carcinoma, typically over 10–20 years. (General & Systemic Pathology SAQ Paper II — 15 July 2025 (MBPA 3500, MKU Year 3,)
Practice questions on Cervical Intraepithelial Neoplasia
Cervical Intraepithelial Neoplasia
- Peaks in incidence at age 20 years
- Is slow but inevitable progression to cervical cancer
- Cannot be prevented by vaccination
- Always manifested by cytological atypia and dysplasia
Answer: D. By definition, CIN represents cytological atypia and dysplasia, which are the cellular changes seen in this precancerous condition. ---