Drug Targets
It is susceptible to antifungals such as azoles and amphotericin B, not to antibiotics, because it lacks bacterial drug targets
What our notes say
- It is susceptible to antifungals such as azoles and amphotericin B, not to antibiotics, because it lacks bacterial drug targets (Medical Virology & Mycology Paper Two 2022/2023 — MKU MBMM 3300 Questions & Answ)
- Understanding replication is essential for understanding pathogenesis — viral replication causes cell damage and death — and for understanding antiviral drug targets, since most antivirals work by blocking specific steps in replication. (EXAM: Basic Virology, Viral Replication, Prions & Slow Viruses, Poxviruses & VZV)
- From a pharmacological standpoint, understanding cancer means understanding what goes wrong at the molecular level so you know what drugs target and why. (Cancer Pharmacology: Cell Cycle, Oncogenes & Drug Targets)
- Common drug targets: receptors, enzymes, ion channels, transporters, nucleic acids (Pharmacology CRASH Course)
- Target: viral polymerases — most important drug target stage (EXAM: Vaccines & Antivirals, Rabies, CMV & EBV, Adenovirus & Enteroviruses)
- Enfuvirtide (Fuzeon) blocks gp41-mediated fusion — another drug target at this step (EXAM: Influenza, Viral Receptors & Spikes, Interferons, and Viral Pathogenesis)
Study material on Drug Targets
- Cancer Pharmacology: Cell Cycle, Oncogenes & Drug Targets
- Pharmco Notes
- EXAM NOTES: VIROLOGY YR3
- Parasitology Examination MCQs
Practice questions on Drug Targets
A component of the cell membrane of most fungi is: Ergosterol is the fungal-membrane sterol analog to cholesterol in humans — the antifungal drug target. ---
- Cholesterol
- Chitin
- Ergosterol
- Peptidoglycan
- Keratin
Answer: C.
Which drug targets the A site of the ribosomes? ---
- Pyrimethamine
- Pentamidine
- Benzimidazoles
- Miltefosine
- Paromomycin
Answer: E.
Which drug targets the dihydropteroate synthase? ---
- Pyrimethamine
- Sulfadoxine
- Benzimidazoles
- Miltefosine
- Paromomycin
Answer: B.
Which drug targets the dihydrofolate reductase? ---
- Pyrimethamine
- Sulfadiazine
- Benzimidazoles
- Nifurtimox
- Sulfadoxine
Answer: A.
Which drug targets the vicynyl sulfhydryl groups of pyruvate kinase? ---
- Pyrimethamine
- Sulfadiazine
- Meglumine antimonate
- Melarsoprol
- Sulfadoxine
Answer: D.
Which of the following drugs targets the A site of parasite ribosome?
- Furazolidone
- Paromomycin
- Tinidazole
- Diloxanide furoate
- Paromomycin (It binds to the A site of the 30S ribosomal subunit
Answer: B.