Fibroadenoma
The stromal component of a phyllodes tumor is more cellular than a fibroadenoma, and it may show atypia or frank malignancy.
Fibroadenoma
- The most common benign tumor of the female breast. It arises from intralobular stroma. Two thirds carry MED12 mutations.
- Most common in women in their 20s and 30s
- Often multiple and bilateral
- Hormonally responsive — grows during pregnancy, shrinks after menopause
- In older women, found as a mammographic density or calcifications rather than a palpable lump
Read this in Stromal Tumors: Fibroadenoma & Phyllodes Tumor Pathology
Fibroadenoma
- The most common benign tumour of the breast , most frequent in women under 30. It is a biphasic tumor of stroma and epithelium. Grossly, it is a well-circumscribed, firm, rubbery, mobile mass ("breast mouse"). Histologically, it shows a loo
Read this in Disorders of the Vagina and Breast
What our notes say
- The stromal component of a phyllodes tumor is more cellular than a fibroadenoma, and it may show atypia or frank malignancy. (Breast mcqs — Past Paper Questions & Answers)
- Young age, painless, mobile, well-circumscribed, stable lesion with smooth borders on ultrasound is the classic profile of a fibroadenoma, the most common benign breast tumour in young women. (Skin & Breast Pathology MCQs: Dermatological Lesions & Diseases)
- Fibroadenoma is a type of proliferative disease without atypia (General Pathology MCQs: Fixatives, FNA, Endocrine & ARDS)
- Fibroadenoma & phyllodes tumor are both driven by MED12 mutations (Exam Prep: Skin Infections, Psoriasis & Pemphigus)
- This is sensitive to hormones and gives rise to breast-specific tumors — fibroadenoma and phyllodes tumor. (Stromal Tumors: Fibroadenoma & Phyllodes Tumor Pathology)
- Fibroadenoma and phyllodes tumor are called biphasic because they contain two components: (Stromal Tumors: Fibroadenoma & Phyllodes Tumor Pathology)
Study material on Fibroadenoma
- Stromal Tumors: Fibroadenoma & Phyllodes Tumor Pathology
- Exam Prep: Skin Infections, Psoriasis & Pemphigus
- Breast mcqs
- Disorders of the Vagina and Breast
- Skin & Breast Pathology CAT: MKU Year 3 Medicine Exam
- Breast Pathology: Developmental Disorders, Pain, Discharge, Masses
- Skin & Breast Pathology MCQs: Dermatological Lesions & Diseases
Practice questions on Fibroadenoma
Which feature best characterises a fibroadenoma of the breast?
- Unilateral bloody nipple discharge in middle-aged women
- Fixed hard mass with skin tethering in older women
- Well-circumscribed mobile rubbery mass in young women
- Bilateral nodularity fluctuating with the menstrual cycle
Answer: C. Fibroadenoma is a well-circumscribed, firm, mobile mass (breast mouse) most common in women under 30. It is composed of both stromal and epithelial elements with no significant malignant potential. ---