Gastric Inhibitory Peptide
Also written as GIP.
Gastric Inhibitory Peptide (GIP), also known as Glucose-dependent Insulinotropic Peptide, is a peptide hormone produced in the duodenum.
What our notes say
- Gastric Inhibitory Peptide (GIP), also known as Glucose-dependent Insulinotropic Peptide, is a peptide hormone produced in the duodenum. (LECTURE 7: GI tract Hormones)
- Gastric Inhibitory Peptide (GIP) — released in response to fats and carbohydrates. (END YEAR PP1 & PP2 2025 Physiology: MCQs for Medical School Exams)
- GIP (Gastric Inhibitory Peptide):Source: Secreted by K-cells in the duodenum and jejunum. (MEDICAL PHYSIOLOGY II ESsays)
- Gastric Inhibitory Peptide (GIP) – Inhibits gastric secretion, stimulates insulin release. (Endocrine LAqs and SAqs)
- Gastric Inhibitory Peptide (GIP): Role in Digestion and Metabolism (LECTURE 7: GI tract Hormones)
Study material on Gastric Inhibitory Peptide
Practice questions on Gastric Inhibitory Peptide
Gastric Inhibitory Peptide (GIP) primarily:
- Stimulates gastric acid
- Stimulates insulin release
- Increases gastric motility
- Decreases pancreatic secretion
Answer: B. GIP is now often called Glucose-dependent Insulinotropic Peptide because its main physiological role is stimulating insulin.
What is the effect of Gastric Inhibitory Peptide (GIP) on the stomach?
- Stimulates motility
- Increases acid secretion
- Inhibits gastric motility and secretion
- Stimulates pepsinogen release
Answer: C. As its name suggests, GIP (also called Glucose-dependent Insulinotropic Peptide) inhibits gastric activity at physiological levels.
Which statement regarding Gastric Inhibitory Peptide (GIP) is true?
- It strongly stimulates gastric acid
- It is secreted in response to glucose and fat in the small intestine
- It inhibits insulin release
- It is produced by the G cells
Answer: B. GIP (also known as Glucose-dependent Insulinotropic Peptide) inhibits gastric activity and stimulates insulin secretion.
Which of the following best describes the function of GIP (Gastric Inhibitory Peptide/Glucose-dependent Insulinotropic Peptide)?
- Stimulates gastric acid secretion.
- Inhibits insulin release from the pancreas.
- Stimulates insulin release from the pancreas in response to glucose.
- Promotes gallbladder contraction.
Answer: C. GIP is released from K cells in the duodenum and jejunum in response to glucose and fat. Its primary role is to stimulate insulin secretion from pancreatic beta cells, particularly after a carbohydrate-rich meal, and it also weakly inhibits gastric acid secretion and motility.
Which of the following best describes the function of GIP (Gastric Inhibitory Peptide)?
- Stimulates gastric acid secretion.
- Inhibits gastric emptying and stimulates insulin release.
- Stimulates gallbladder contraction.
- Promotes pancreatic bicarbonate secretion.
Answer: B. GIP is released from K cells in the duodenum and jejunum in response to glucose and fat. Its primary physiological roles are to inhibit gastric acid secretion and emptying (hence 'gastric inhibitory peptide') and, importantly, to stimulate insulin release from pancreatic beta cells (an 'incretin' effect), anticipating the rise in blood glucose from absorbed nutrients.