Great Arteries

Q: In Transposition of Great Arteries (TGA), which embryological failure is responsible?

Failure of the aorticopulmonary septum to spiral. TGA occurs when the aorticopulmonary septum fails to spiral normally, resulting in the aorta arising from the RV and the pulmonary artery from the LV.

Q: In Transposition of Great Arteries, which embryological failure is directly responsible?

Resorption of subpulmonary instead of subaortic conus. Normally the subaortic conus resorbs, moving the aorta posteriorly to connect with the LV. In TGA the wrong conus resorbs, keeping the aorta anterior and connected to the RV.

Also written as TGA.

diseases—transposition of great arteries is an example. (choreoathetoid cerebral palsy and deafness).

What our notes say

diseases—transposition of great arteries is an example. (choreoathetoid cerebral palsy and deafness). (Devendra K. Gupta, Krishna M. Goel - Hutchison’s Paediatrics. chdhe-Jaypee Broth)
tetralogy of Fallot, transposition of the great arteries, and corresponding increase in perfusion, tissue hypoxia (Harrisons Pulmonary and Critical Care Medicine)
This click-murmur complex will move away great arteries. (Harrisons Cardiovascular Medicine 2nd Edition 2)
19), such as transposition of the great arteries, ostium primum atrial septal defects (ASDs), ventric- consequence of catheter ablation. (Harrisons Cardiovascular Medicine 2nd Edition 2)
Clinical presentation:\nof the great arteries with or without VSD, and coarctation (Devendra K. Gupta, Krishna M. Goel - Hutchison’s Paediatrics. chdhe-Jaypee Broth)
great arteries and aortic arch − Truncus overlies a ventral septal defect (always present) and receives blood from (Kaplan Pediatrics pdf-notes 201506051322 - flattened (2))

Study material on Great Arteries

Practice questions on Great Arteries

In Transposition of Great Arteries (TGA), which embryological failure is responsible?

Failure of the aorticopulmonary septum to spiral
Abnormal neural crest migration
Failure of pulmonary vein incorporation
Atrophy of the right aortic arch

Answer: A. TGA occurs when the aorticopulmonary septum fails to spiral normally, resulting in the aorta arising from the RV and the pulmonary artery from the LV.

In Transposition of Great Arteries, which embryological failure is directly responsible?

Resorption of subpulmonary instead of subaortic conus
Failure of subaortic conus to elongate
Failure of truncus arteriosus to partition
Malalignment of the outlet septum anteriorly

Answer: A. Normally the subaortic conus resorbs, moving the aorta posteriorly to connect with the LV. In TGA the wrong conus resorbs, keeping the aorta anterior and connected to the RV.