Hemolytic Uremic Syndrome
Also written as HUS.
Hemolytic Uremic Syndrome (HUS) shares features with TTP but typically affects children, is often triggered by E. coli O157:H7 toxin, and is dominated by severe renal failure with normal ADAMTS13 levels.
What our notes say
- Hemolytic Uremic Syndrome (HUS) shares features with TTP but typically affects children, is often triggered by E. coli O157:H7 toxin, and is dominated by severe renal failure with normal ADAMTS13 levels. (Platelet Disorders)
- In which two conditions are platelet transfusions generally contraindicated due to the risk of worsening thrombosis? → Thrombotic Thrombocytopenic Purpura (TTP) and Hemolytic Uremic Syndrome (HUS). (Platelet Disorders)
- Shiga toxin — inhibits protein synthesis by acting on the ribosome (60S subunit), causing cell death; contributes to bloody dysentery and can cause hemolytic uremic syndrome in severe cases (Streptococcus Classification, S. pyogenes, Rheumatic Fever, AGN)
- Complications: Hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (Medical Microbiology Q&A Guide)
Study material on Hemolytic Uremic Syndrome
- Platelet Disorders
- Exam Prep: Skin Infections, Psoriasis & Pemphigus
- Medical Microbiology Q&A Guide
- MEDICAL BACTERIOLOGY (MBMM3311) - MCQs
- Medical Bacteriology MCQs
Practice questions on Hemolytic Uremic Syndrome
A patient develops hemolytic uremic syndrome (HUS) after eating undercooked hamburger. The organism is
- Shigella dysenteriae
- Escherichia coli O157:H7
- Salmonella enteritidis
- Campylobacter jejuni
- coli (EHEC), particularly O157:H7, produces Shiga toxin causing hemorrhagic col
Answer: E. Enterohemorrhagic E. coli (EHEC), particularly O157:H7, produces Shiga toxin causing hemorrhagic colitis that can progress to HUS with acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. Transmitted via contaminated beef. ---
A patient develops hemolytic uremic syndrome (HUS) after eating undercooked hamburger. The organism is
- Shigella dysenteriae
- Escherichia coli O157:H7
- Salmonella enteritidis
- Campylobacter jejuni
- Primarily an incidental laboratory finding
Answer: B. EHEC O157:H7 produces Shiga toxin causing hemorrhagic colitis and HUS. ---