Glomerulonephritis
Lung haemorrhage plus glomerulonephritis with anti-GBM antibodies is Goodpasture's syndrome.
What our notes say
- Lung haemorrhage plus glomerulonephritis with anti-GBM antibodies is Goodpasture's syndrome. (Junior Clerkship in Internal Medicine (MBIM4100) main exam, Paper One: 31 Januar)
- Post-streptococcal glomerulonephritis is likely to be the diagnosis here (Paediatrics main exam (MBPE 4300): 24 January 2022, Paper One, 100 MCQs, 2 short)
- Cola-coloured urine, hypertension and a recent throat infection fit post-streptococcal glomerulonephritis, and the seizure is hypertensive encephalopathy. (Paediatrics main exam (MBPE 4300): 24 January 2022, Paper One, 100 MCQs, 2 short)
- | Renal (intrinsic) | The kidney itself is damaged | Acute tubular necrosis (ATN) from ischaemia or toxins (aminoglycosides, contrast, herbal remedies); glomerulonephritis; interstitial nephritis (drugs, infection); blackwater fever in malaria; rhabdomyolysis | (Acute kidney injury)
- Biopsy shows diffuse proliferative glomerulonephritis (WHO class IV). (Internal Medicine Rheumatology CAT: 30 MCQs and 5 short answer questions)
- Dysmorphic RBCs and proteinuria show glomerulonephritis. (Internal Medicine End of Semester CAT (MBChB 4): haematology and renal, 30 MCQs )
Study material on Glomerulonephritis
- renal pathology
- Paediatrics main exam (MBPE 4300): 24 January 2022, Paper One, 100 MCQs, 2 short essays and 2 long essays
- Streptococcus Classification, S. pyogenes, Rheumatic Fever, AGN
- FSGS & HIV Nephropathy: Causes, Symptoms, Diagnosis & Prognosis
- Glomerular Diseases: Classification, Histology & Pathology
- Acute kidney injury
- Chemical Pathology MCQs: Clinical Chemistry, Endocrine & Renal
- Internal Medicine End of Semester CAT (MBChB 4): haematology and renal, 30 MCQs and 3 short answers
- Paediatrics end of 3rd trimester exam (MBPE 4300): 11 January 2022, congenital heart disease essay and 20 MCQs
- Paediatrics end of fourth year main exam: 1 July 2019, Paper One, 99 of 100 MCQs and essays
Practice questions on Glomerulonephritis
A 40-year-old man with proliferative glomerulonephritis has elevated ANA and anti-ds-DNA. Most likely cardiac abnormality?
- Pancarditis
- Libman-Sacks endocarditis
- Hemorrhagic pericarditis
- Lipofuscin deposition
Answer: B. Elevated ANA + anti-ds-DNA + glomerulonephritis = SLE. Libman-Sacks endocarditis — sterile small vegetations on the mitral and tricuspid valves — is the classic cardiac manifestation. ---
A 35-year-old presents with hemoptysis, anemia, diffuse pulmonary infiltrates, and rapidly progressive glomerulonephritis. Lung biopsy shows linear IgG deposition. The target antigen is
- α3 chain of collagen IV
- Double-stranded DNA
- Neutrophil proteinase-3
- Myeloperoxidase antigen
Answer: A. Goodpasture syndrome is caused by antibodies targeting the noncollagenous domain of the α3 chain of collagen IV, affecting both pulmonary and glomerular basement membranes. ---