Rapidly Progressive Glomerulonephritis
Also written as RPGN.
Glomerular: post-streptococcal glomerulonephritis and rapidly progressive glomerulonephritis.
What our notes say
- Glomerular: post-streptococcal glomerulonephritis and rapidly progressive glomerulonephritis. (Paediatrics end of fourth year main exam: 1 July 2019, Paper One, 99 of 100 MCQs)
- Rapidly progressive glomerulonephritis (RPGN): the creatinine keeps rising over days to weeks; crescents on biopsy. (Acute kidney injury)
- This results in rapidly progressive glomerulonephritis and pulmonary hemorrhage, fitting the description perfectly. (General Pathology Q&A)
- These antibodies trigger destruction and inflammation, leading to necrotizing hemorrhagic interstitial pneumonitis and rapidly progressive glomerulonephritis. (Lung Pathology — Must-Know)
- Workup also reveals rapidly progressive glomerulonephritis. (Respiratory System Pathology 1A)
Study material on Rapidly Progressive Glomerulonephritis
- FSGS & HIV Nephropathy: Causes, Symptoms, Diagnosis & Prognosis
- Nephrotic and nephritic syndromes
- renal pathology
- Glomerular Diseases: Classification, Histology & Pathology
- Male Reproductive & Urinary Tract Pathology MCQs | MKU Year 3 Medicine
Practice questions on Rapidly Progressive Glomerulonephritis
A 35-year-old presents with hemoptysis, anemia, diffuse pulmonary infiltrates, and rapidly progressive glomerulonephritis. Lung biopsy shows linear IgG deposition. The target antigen is
- α3 chain of collagen IV
- Double-stranded DNA
- Neutrophil proteinase-3
- Myeloperoxidase antigen
Answer: A. Goodpasture syndrome is caused by antibodies targeting the noncollagenous domain of the α3 chain of collagen IV, affecting both pulmonary and glomerular basement membranes. ---