Mantle Cell Lymphoma
Also written as MCL.
Mantle cell lymphoma — cyclin D1 overexpression from t(11;14) requires urgent treatment
What our notes say
- Mantle cell lymphoma — cyclin D1 overexpression from t(11;14) requires urgent treatment (Haematopathology MCQs: Blood Disorders & Anemia Explained)
- Mantle cell lymphoma — t(11;14) causing BCL2 overexpression, requiring bendamustine/rituximab (Haematopathology MCQs: Blood Disorders & Anemia Explained)
- Abnormal expression in: breast, oesophagus, head and neck, liver, mantle cell lymphoma (Hallmarks of Cancer: Molecular Basis, Cell Cycle & Oncogenes)
- *Mature B-cell:* CLL/SLL, Follicular lymphoma, Diffuse large B-cell lymphoma (DLBCL), Mantle cell lymphoma, Burkitt lymphoma, MALT lymphoma, Hairy cell leukaemia, Plasma cell myeloma. (Lymphoma Overview and Classification)
- Mantle Cell Lymphoma: t(11;14) → Cyclin D1 overexpression. (Lymphoma Overview and Classification)
Practice questions on Mantle Cell Lymphoma
Which translocation is required for the diagnosis of Mantle Cell Lymphoma?
- t(14;18)
- t(8;14)
- t(2;5)
- t(11;14)
Answer: D. This juxtaposes the Cyclin D1 gene to the Ig heavy-chain gene → Cyclin D1 overexpression. Its presence is required for MCL diagnosis. ---
Which translocation is required for the diagnosis of Mantle Cell Lymphoma?
- t(14;18)
- t(8;14)
- t(11;14)
- t(11;18)
Answer: C. Mantle Cell Lymphoma is defined by the t(11;14) translocation, which leads to overexpression of Cyclin D1. ---