Anaplastic Large Cell Lymphoma
Also written as ALCL.
*Mature T/NK-cell:* Mycosis fungoides, Adult T-cell leukaemia (HTLV-1), Anaplastic large cell lymphoma (ALCL), Peripheral T-cell lymphoma.
What our notes say
- *Mature T/NK-cell:* Mycosis fungoides, Adult T-cell leukaemia (HTLV-1), Anaplastic large cell lymphoma (ALCL), Peripheral T-cell lymphoma. (Lymphoma Overview and Classification)
Study material on Anaplastic Large Cell Lymphoma
- Lymphoma Overview and Classification
- Non-Hodgkin Lymphoma: Classification, Symptoms, Diagnosis, and Treatment
- Non-Hodgkin Lymphoma: Classification, Symptoms, Diagnosis, and Treatment — Practice Questions
- MCQ: Hematopathology
Practice questions on Anaplastic Large Cell Lymphoma
Anaplastic Large Cell Lymphoma (ALCL) is associated with which translocation and its resulting overexpressed protein?
- t(14;18) → BCL-2
- t(11;14) → Cyclin D1
- t(2;5) → ALK
- t(8;14) → MYC
Answer: C. t(2;5) causes overexpression of anaplastic lymphoma kinase (ALK). ALK+ ALCL has better prognosis than ALK− ALCL. Crizotinib specifically inhibits ALK. ---