Gastric MALT Lymphoma
What type of gastric lymphoma is most likely, and what is its initial management strategy? → Gastric MALT Lymphoma; *H. pylori* eradication.
Gastric MALT Lymphoma
- Derived from mucosa-associated lymphoid tissue (MALT)
- MALT is not normally present in the stomach — develops in response to chronic H. pylori gastritis
- H. pylori eradication → tumour regression in early-stage disease
- Most common primary gastric lymphoma
Read this in Gastropathology Pathology
Gastric MALT Lymphoma
- Derived from mucosa-associated lymphoid tissue (MALT) induced by chronic H. pylori gastritis.
- H. pylori eradication can lead to tumour regression in early stages.
Read this in Tumours of the Gastrointestinal Tract
What our notes say
- What type of gastric lymphoma is most likely, and what is its initial management strategy? → Gastric MALT Lymphoma; *H. pylori* eradication. (Gastrointestinal Neoplasms: High-Yield Exam Review)
- Gastric MALT Lymphoma: Develops secondary to chronic *H. pylori* gastritis; early-stage disease may regress with *H. pylori* eradication. (Gastropathology Pathology)
- | Gastric MALT Lymphoma | Stomach | *H. pylori* induced; regresses with eradication | (Gastropathology Pathology)
- Gastric MALT Lymphoma: A primary gastric lymphoma developing in response to chronic *H. pylori* gastritis. (Gastrointestinal Neoplasms: High-Yield Exam Review)
Study material on Gastric MALT Lymphoma
- Gastropathology Pathology
- Gastrointestinal Neoplasms: High-Yield Exam Review
- MCQ: Hematopathology
- Weekly Pathology Exam - March 7, 2026 (Section A: MCQs)
Practice questions on Gastric MALT Lymphoma
Which organism is directly implicated in the pathogenesis of gastric MALT lymphoma?
- Epstein-Barr virus
- HTLV-1
- Helicobacter pylori
- HHV-8
Answer: C. Gastric MALT lymphoma is strongly linked to H. pylori. Early-stage disease can regress completely with antibiotics alone. ---
What is the first-line treatment for early-stage gastric MALT lymphoma?
- R-CHOP chemotherapy
- Radiotherapy
- H. pylori eradication with antibiotics
- Rituximab monotherapy
Answer: C. In early-stage gastric MALT, eliminating H. pylori can be curative. Chemotherapy is reserved for advanced or refractory disease. ---
Which organism is directly implicated in the pathogenesis of gastric MALT lymphoma?
- Epstein-Barr Virus
- Helicobacter pylori
- Hepatitis C Virus
- Human T-cell Leukemia Virus
Answer: B. Chronic gastrtitis caused by H. pylori provides the antigenic stimulus for B-cell proliferation in the stomach, leading to MALT lymphoma. ---
What is the first-line treatment for early-stage gastric MALT lymphoma?
- CHOP chemotherapy
- Radiation therapy
- H. pylori eradication (antibiotics/PPI)
- Total gastrectomy
Answer: C. Most cases of early-stage gastric MALT lymphoma regress completely after eradication of H. pylori. ---