Oesophageal Squamous Cell Carcinoma
Also written as SCC.
Which type of oesophageal carcinoma is most likely, and what additional risk factor might be relevant in this demographic? → Oesophageal Squamous Cell Carcinoma (SCC); HPV infection (in high-risk regions)
Oesophageal Squamous Cell Carcinoma (SCC)
- Who : Adults 45 yrs; males 4× more; 6× more in African Americans than whites (NOT fully explained by alcohol/tobacco); incidence varies 100-fold between countries
- High-incidence countries : Iran, central China, Hong Kong, Argentina, Brazil, South Africa
- Risk Factors : Alcohol + tobacco (synergistic), poverty, nutritional deficiencies, caustic oesophageal injury, achalasia, Plummer-Vinson syndrome, very hot beverages, mediastinal radiation, polycyclic hydrocarbons, nitrosamines, fungus-cont
- Location : Middle 1/3 of oesophagus (contrast: adenocarcinoma = distal 1/3)
- Gross : Early = small grey-white plaque-like thickenings → Later = polypoid/obstructing OR ulcerated OR diffusely infiltrative (wall thickening + luminal narrowing)
Read this in Gastropathology Pathology
Oesophageal Squamous Cell Carcinoma (SCC)
- Demographics: Adults 45 yrs; males 4× more; higher incidence in African Americans.
- Risk Factors: Alcohol and tobacco (synergistic), poverty, nutritional deficiencies, caustic injury, achalasia, Plummer-Vinson syndrome, hot beverages, HPV (high-risk regions).
- Location: Middle 1/3 of oesophagus.
- Gross: Grey-white plaque-like thickenings; later polypoid/obstructing or ulcerated.
- Microscopy: Moderately to well differentiated; variants include verrucous and spindle cell.
Read this in Tumours of the Gastrointestinal Tract
What our notes say
- Which type of oesophageal carcinoma is most likely, and what additional risk factor might be relevant in this demographic? → Oesophageal Squamous Cell Carcinoma (SCC); HPV infection (in high-risk regions) (Gastropathology Pathology)
- Which oesophageal cancer is strongly associated with synergistic alcohol and tobacco use and typically affects the middle 1/3 of the oesophagus? → Oesophageal Squamous Cell Carcinoma. (Gastrointestinal Neoplasms: High-Yield Exam Review)
- Oesophageal Squamous Cell Carcinoma (SCC): Found in the middle 1/3, strongly linked to alcohol and tobacco synergy, and HPV in high-risk regions. (Gastropathology Pathology)
- Oesophageal Squamous Cell Carcinoma (SCC): Typically affects the middle 1/3 of the oesophagus. (Gastrointestinal Neoplasms: High-Yield Exam Review)