Colorectal Cancer
Also written as CRC.
Reduced risk of ovarian and endometrial cancer (and colorectal cancer)
Treatment at a glance
- Surgery; adjuvant FOLFOX (5-FU, folinic acid, oxaliplatin) or capecitabine for stage III
What our notes say
- Reduced risk of ovarian and endometrial cancer (and colorectal cancer) (Year 4 Gynaecology CAT 2 (MBOG 4212): 8 October 2021)
- Ulcerative colitis raises the risk of colorectal cancer and primary sclerosing cholangitis. (Endocrinology and Gastroenterology Question Bank: 12 Clinical MCQs)
- Blood loss: hookworm and schistosomiasis, peptic ulcer, heavy menstrual bleeding, postpartum haemorrhage, colorectal cancer. (Approach to anaemia)
- Risk factors: familial adenomatous polyposis, hereditary non-polyposis colorectal cancer (Lynch syndrome), inflammatory bowel disease, low-fibre diet, adenomatous polyps (Pathology Practical Revision Guide)
- | Complications | Fistulas, strictures, malabsorption | Toxic megacolon, ↑colorectal cancer risk (higher than Crohn's) | (Essential Cardiovascular Pathology: Atherosclerosis to Endoc)
- Risk factors: familial adenomatous polyposis (APC gene), hereditary non-polyposis colorectal cancer (Lynch syndrome), inflammatory bowel disease, low-fibre/high-fat diet, age (Cardiovascular, Respiratory & GI/Hepatobiliary Pathology Revision (MBPA 3500 Pap)
Study material on Colorectal Cancer
- Ovarian & Colorectal Cancer: Risks, Pathogenesis, Staging
- Gastrointestinal Neoplasms: High-Yield Exam Review
- Gastropathology Pathology
- Molecular Basis of Cancer: Cell Cycle, Apoptosis & Angiogenesis
- Chemical Pathology MCQs: Clinical Chemistry, Endocrine & Renal
- CRUSH COURSE (PART 2) Clinical Chem Patho
- Cancer Pharmacology: Cell Cycle, Oncogenes & Drug Targets
- Chemical Pathology MCQs
Practice questions on Colorectal Cancer
A 72-year-old patient undergoes a CT scan which reveals multiple, often ill-defined, hypodense lesions throughout both lobes of the liver. The patient has a known history of colorectal cancer diagnosed 2 years prior. What is the most probable origin of these liver lesions?
- Primary liver cancer (HCC)
- Cholangiocarcinoma
- Metastatic disease from colorectal primary
- Benign liver cysts
Answer: C. The most common source of metastatic liver disease is colorectal cancer, and multiple lesions throughout the liver are highly characteristic of metastasis rather than a primary tumor. ---