Mismatch Repair
Also written as MMR.
Defects in DNA mismatch repair genes (MLH1, MSH2) are associated with:
What our notes say
- Defects in DNA mismatch repair genes (MLH1, MSH2) are associated with: (General Pathology MCQs: Cancer, Tumors & Molecular Path Review)
- Errors that escape proofreading are corrected by the Mismatch Repair Mechanism. (Types of Mutations in ARBHN (Amino Acid Replacement Based on Hemoglobin to Produ)
- This condition arises from abnormal mismatch repair genes and accounts for perhaps 1 to 3% of all colon cancers. (Gastrointestinal and liver — Past Paper Questions & Answers)
- Defective DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2) (Ovarian & Colorectal Cancer: Risks, Pathogenesis, Staging)
- Alternative pathway: Lynch syndrome/HNPCC follows the microsatellite instability pathway (mismatch repair gene mutations — MLH1, MSH2), distinct from the APC/chromosomal instability pathway above (Essential Cardiovascular Pathology: Atherosclerosis to Endoc)
- *Germline mutations in mismatch repair genes (MLH1, MSH2, etc.) cause Lynch syndrome/HNPCC, predisposing to microsatellite-unstable colorectal and endometrial cancers.* (General Pathology MCQs: Cancer, Tumors & Molecular Path Review)
Study material on Mismatch Repair
- Gastropathology Pathology
- General Pathology MCQs: Cancer, Tumors & Molecular Path Review
- Hallmarks of Cancer: Molecular Basis, Cell Cycle & Oncogenes
- Molecular Biology,Molecular Genetics & Microbial-Biochemistry MCQs
- GASTROINTESTINAL PATHOLOGY (Part 2)
- Gastrointestinal Neoplasms: High-Yield Exam Review
Practice questions on Mismatch Repair
Defects in DNA mismatch repair genes (MLH1, MSH2) are associated with:
- Chronic inflammation
- Hereditary nonpolyposis colorectal cancer (Lynch syndrome)
- BRCA1 mutation
- Burkitt lymphoma
- Philadelphia chromosome
Answer: B. Defects in DNA mismatch repair genes like MLH1 and MSH2 are the genetic basis for Hereditary Nonpolyposis Colorectal Cancer (Lynch syndrome).
Defects in DNA mismatch repair genes (MLH1, MSH2) are associated with ---
- Chronic inflammation
- Hereditary nonpolyposis colorectal cancer (Lynch syndrome)
- BRCA1 mutation
- Burkitt lymphoma
- Philadelphia chromosome
Answer: B.