Sex Hormones
Interestingly, uterine fibroids (leiomyomas) also carry MED12 mutations — both the breast and uterus are organs sensitive to female sex hormones.
What our notes say
- Interestingly, uterine fibroids (leiomyomas) also carry MED12 mutations — both the breast and uterus are organs sensitive to female sex hormones. (Stromal Tumors: Fibroadenoma & Phyllodes Tumor Pathology)
- Hormones: growth hormone, thyroid hormone, insulin and sex hormones. (Growth and Development in Children)
- Hyperinsulinaemia also suppresses hepatic SHBG (sex hormone-binding globulin) production → increases free (bioactive) testosterone (Ovarian & Colorectal Cancer: Risks, Pathogenesis, Staging)
- | Combined oral contraceptive pill (COCP) | ↑ sex hormone-binding globulin (SHBG) → ↓ free androgens → ↓ sebaceous gland stimulation | Licensed for acne: ethinyl estradiol + norgestimate/drospirenone/cyproterone | (Pharmco Notes)
- Functions of Adrenal Androgens:Precursors for sex hormones (testosterone and estrogen) (Chemical Pathology Practice Examination)
- Sex: Hormone differences (testosterone in males, estrogen in females) (Clinical Biochemistry - Comprehensive Study Notes)