Aldehyde Dehydrogenase
Also written as ALDH.
Like disulfiram (Antabuse®),\nnitroimidazoles inhibit aldehyde dehydrogenase, leading to an\nunpleasant reaction due to acetaldehyde accumulation when\nalcohol is consumed\nAdvice Patients should be warned about the reaction to alcohol
What our notes say
- Like disulfiram (Antabuse®),\nnitroimidazoles inhibit aldehyde dehydrogenase, leading to an\nunpleasant reaction due to acetaldehyde accumulation when\nalcohol is consumed\nAdvice Patients should be warned about the reaction to alcohol (Davidson's Essentials of Medicine - 2nd)
- Formaldehyde is further oxidized by aldehyde dehydrogenase to formic acid (Medical Biochemistry II: MBMB 2200 Paper A Answer Key — Part 5)
- Acetaldehyde is oxidized to acetate by aldehyde dehydrogenase (Medical Biochemistry II: MBMB 2200 Paper A Answer Key — Part 5)
- Methanol Metabolism in the Liver:Methanol is oxidized by alcohol dehydrogenase (ADH) into formaldehyde, which is then rapidly converted by aldehyde dehydrogenase (ALDH) into formic acid, the primary toxic agent. (Clinical Biochemistry: LAQs and SAQs — Past Paper)
- Acetaldehyde → Acetate (via aldehyde dehydrogenase in mitochondria) (Medical Biochemistry: Specialized Tissues and Exercise Metabolism — Notes)
- Formaldehyde rapidly oxidized by aldehyde dehydrogenase (Medical Biochemistry: Specialized Tissues and Exercise Metabolism — Notes)