Diabetics Complications
This is particularly important in diabetic complications where excess glucose leads to sorbitol accumulation in tissues like the eye.
What our notes say
- This is particularly important in diabetic complications where excess glucose leads to sorbitol accumulation in tissues like the eye. (Medical Biochemistry II: MBMB 2200 Paper A Answer Key — Part 5)
- Diabetic complications (Box 11.9) may be the presenting finding in (Davidson's Essentials of Medicine - 2nd)
- of diabetic complications in patients with type 1 diabetes on inten (Davidson's Essentials of Medicine - 2nd)
Study material on Diabetics Complications
Practice questions on Diabetics Complications
The polyol pathway in diabetic complications involves
- Activation of protein kinase C causing vascular dysfunction
- Aldose reductase converting excess glucose to sorbitol → osmotic damage to cells (lens, nerves, kidneys)
- Non-enzymatic glycation of proteins forming AGEs
- Hexosamine pathway activation causing endothelial dysfunction
Answer: B. Four key mechanisms of diabetic microvascular complications: (1) Polyol pathway — sorbitol accumulation (lens → cataracts, nerves → neuropathy). (2) AGEs — glycation of proteins/vessels. (3) PKC activation — vascular permeability, angiogenesis. (4) Hexosamine pathway. Aldose reductase inhibitors (e.g. epalrestat) target the polyol pathway. Know all four mechanisms for exams.