Biopsy Confirms Squamous Cell Carcinoma
Also written as SCC.
Practice questions on Biopsy Confirms Squamous Cell Carcinoma
A 58-year-old man with a 30-pack-year smoking history presents with a persistent non-healing ulcer on the floor of the mouth. Biopsy confirms squamous cell carcinoma (SCC). Which site is most associated with classic HPV-negative keratinising SCC of the oral cavity?
- Hard palate only
- Dorsal tongue only
- Ventral tongue and floor of mouth
- Buccal mucosa exclusively
- Upper lip only ✅ Answer: C
Answer: A. The floor of the mouth and ventral surface of the tongue are common sites for HPV-negative, keratinizing squamous cell carcinoma in smokers.